Biomarkers of individual susceptibility to carcinogens: Application for biological monitoring
| Autor: | O. S. Yatsuk, D. Sh. Beniashvili, O. I. Kazanova, V. B. Yermilov, A. J. Likhachev, M. A. Zabezhinski, V. J. Bykov, Natalia A. Loktionova, M. L. Tyndyk |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Lung Neoplasms DNA Repair DNA repair Biology Dihydroxydihydrobenzopyrenes O(6)-Methylguanine-DNA Methyltransferase Stomach Neoplasms Benzo(a)pyrene Gastric mucosa medicine Animals Humans Benzopyrenes Child Stomach cancer Lung cancer Carcinogen Gastric Juice Stomach Smoking Age Factors Public Health Environmental and Occupational Health O-6-methylguanine-DNA methyltransferase DNA Methyltransferases Middle Aged medicine.disease Rats Macaca fascicularis medicine.anatomical_structure Gastric Mucosa Gastritis Carcinogens Cancer research Female Disease Susceptibility Biomarkers Environmental Monitoring Nitroso Compounds Alkyltransferase |
| Zdroj: | International Archives of Occupational and Environmental Health. 65:S155-S158 |
| ISSN: | 1432-1246 0340-0131 |
| Popis: | In order to develop new markers of individual susceptibility to various human carcinogens, we studied some parameters of formation and metabolism of carcinogens, as well as DNA adducts formation and DNA repair in animals and humans. Following an i.p. administration of benzo(a)pyrene (BP) to the rats, levels of urinary excretion of BP-7,8-diol correlated with tumour latency. A high correlation was found between excretion of this metabolite and BP-DNA adducts level in the liver. Healthy smokers excreted higher quantities of BP-7,8-diol, than smoking lung cancer patients, thus confirming the suggestion on existence of cancer-prone phenotype. N-nitroso compounds formed most efficiently in stomach juice of children with superficial gastritis who therefore could be at high risk of stomach cancer. N-ethyl-N'-nitro-N-nitrosoguanidine induced stomach cancer earlier in monkeys with a low level of DNA repair enzyme, O6-alkylguanine-DNA alkyltransferase (AGT) in gastric mucosa. Overall, these markers can be helpful in predicting individual susceptibility to carcinogens. |
| Databáze: | OpenAIRE |
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