A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study
| Autor: | M. Pařízek, Alena Lodererová, Eduard Brynda, Martin Čapek, Ivo Skalský, Zuzana Burdikova, Lucie Bacakova, A. Lytvynets, Jana Maluskova, Ondrej Szarszoi, V. Lisa, Elena Filova, Jan Pirk |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Tissue Fixation Intimal hyperplasia Polyesters Pharmaceutical Science Perivascular wrap Cell Count Muscle Smooth Vascular Veins Restenosis Chinchilla Proliferating Cell Nuclear Antigen medicine Animals cardiovascular diseases Vein Controlled drug release Cell Proliferation Drug Implants Sirolimus Hyperplasia Paraffin Embedding business.industry Graft Occlusion Vascular Autologous vein Surgical Mesh equipment and supplies medicine.disease Tunica intima Immunohistochemistry Surgery surgical procedures operative Surgical mesh medicine.anatomical_structure cardiovascular system Rabbit model Rabbits Tunica Intima Tunica Media Complication business Nuclear medicine Immunosuppressive Agents medicine.drug |
| Zdroj: | International Journal of Pharmaceutics. 427(2):311-319 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2012.02.023 |
| Popis: | The main complication of aortocoronary reconstruction with vein grafts is restenosis in the course of time. The aim was to assess the effect of a periadventitial polyester mesh releasing sirolimus on intimal hyperplasia of autologous grafts. We implanted v. jugularis ext. into a. carotis communis in rabbits. The vein graft was either intact, or was wrapped with a pure polyester mesh, or with a sirolimus-releasing mesh. Three and six weeks after surgery, the veins were subjected to standard histological staining and the thicknesses of the tunica intima, the media and the intima-media complex were measured. Wrapping the vein with a mesh releasing sirolimus or with a pure mesh decreased the thickness of the intima in comparison with a vein graft by 73 ± 11% or 73 ± 8% after 3 weeks, and by 73 ± 9% or 59 ± 12% after 6 weeks, respectively. Sirolimus-releasing meshes reduced the thickness of the media by 65 ± 9% and 20 ± 12% after 3 and 6 weeks. The thickness of the intima-media complex in grafts with sirolimus-releasing meshes decreased by 60 ± 6% and 30 ± 13% in comparison with pure PES meshes, after 3 and 6 weeks, respectively. A periadventitial polyester mesh releasing sirolimus has the potential to become an effective device in preventing vein graft restenosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect