Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumor with sarcomatous morphology and distant metastases: An unusual histomorphology and behavior

Autor: Abhishek Allam, Bhawna Sethi, Trupti Pai, Sridhar Epari
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Microbiology (medical)
Pathology
medicine.medical_specialty
Necrosis
Lung Neoplasms
Anaplastic lymphoma kinase gene
Fibrosarcoma
lcsh:QR1-502
Biology
lcsh:Microbiology
Pathology and Forensic Medicine
Neoplasms
Muscle Tissue
hemic and lymphatic diseases
anaplastic lymphoma kinase-protein
medicine
lcsh:Pathology
Anaplastic lymphoma kinase
Neoplasm
Humans
Anaplastic Lymphoma Kinase
Neoplasm Metastasis
inflammatory myofibroblastic sarcoma
In Situ Hybridization
Gene Rearrangement
Microscopy
crizotinib
medicine.diagnostic_test
Crizotinib
Histocytochemistry
Receptor Protein-Tyrosine Kinases
General Medicine
Gene rearrangement
Middle Aged
medicine.disease
Immunohistochemistry
fluorescence in-situ hybridization
Cancer research
Female
medicine.symptom
Fluorescence in situ hybridization
medicine.drug
lcsh:RB1-214
Zdroj: Indian Journal of Pathology and Microbiology, Vol 58, Iss 4, Pp 509-512 (2015)
ISSN: 0377-4929
Popis: Inflammatory myofibroblastic tumor (IMT), an intermediate-grade neoplasm of myofibroblastic/fibroblastic differentiation, occurs commonly in children and young adults. It is characterized by anaplastic lymphoma kinase (ALK) gene rearrangement and overexpression of ALK-protein. However, aggressive behavior is more commonly associated with ALK-negativity rather than ALK-positivity. Pulmonary involvement is most common visceral location and carries minimal potential for distant metastasis. We present a case of 49-year-old female with pulmonary IMT of spindle cell sarcomatous histomorphology. Frequent mitoses and necrosis with characteristic cytoplasmic immunoreactivity for ALK-1 protein and ALK-gene rearrangement on fluorescence in-situ hybridization were noted. This case is unusual for occurrence in higher age-group of fifth decade, sarcomatous histomorphology at presentation (rather than transformation) and metastases to distant sites despite ALK-protein overexpression and gene rearrangement.
Databáze: OpenAIRE
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