Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumor with sarcomatous morphology and distant metastases: An unusual histomorphology and behavior
Autor: | Abhishek Allam, Bhawna Sethi, Trupti Pai, Sridhar Epari |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Microbiology (medical)
Pathology medicine.medical_specialty Necrosis Lung Neoplasms Anaplastic lymphoma kinase gene Fibrosarcoma lcsh:QR1-502 Biology lcsh:Microbiology Pathology and Forensic Medicine Neoplasms Muscle Tissue hemic and lymphatic diseases anaplastic lymphoma kinase-protein medicine lcsh:Pathology Anaplastic lymphoma kinase Neoplasm Humans Anaplastic Lymphoma Kinase Neoplasm Metastasis inflammatory myofibroblastic sarcoma In Situ Hybridization Gene Rearrangement Microscopy crizotinib medicine.diagnostic_test Crizotinib Histocytochemistry Receptor Protein-Tyrosine Kinases General Medicine Gene rearrangement Middle Aged medicine.disease Immunohistochemistry fluorescence in-situ hybridization Cancer research Female medicine.symptom Fluorescence in situ hybridization medicine.drug lcsh:RB1-214 |
Zdroj: | Indian Journal of Pathology and Microbiology, Vol 58, Iss 4, Pp 509-512 (2015) |
ISSN: | 0377-4929 |
Popis: | Inflammatory myofibroblastic tumor (IMT), an intermediate-grade neoplasm of myofibroblastic/fibroblastic differentiation, occurs commonly in children and young adults. It is characterized by anaplastic lymphoma kinase (ALK) gene rearrangement and overexpression of ALK-protein. However, aggressive behavior is more commonly associated with ALK-negativity rather than ALK-positivity. Pulmonary involvement is most common visceral location and carries minimal potential for distant metastasis. We present a case of 49-year-old female with pulmonary IMT of spindle cell sarcomatous histomorphology. Frequent mitoses and necrosis with characteristic cytoplasmic immunoreactivity for ALK-1 protein and ALK-gene rearrangement on fluorescence in-situ hybridization were noted. This case is unusual for occurrence in higher age-group of fifth decade, sarcomatous histomorphology at presentation (rather than transformation) and metastases to distant sites despite ALK-protein overexpression and gene rearrangement. |
Databáze: | OpenAIRE |
Externí odkaz: |