Association between statin use and perioperative mortality after aortobifemoral bypass in patients with aortoiliac occlusive disease
| Autor: | Hanaa Dakour-Aridi, Satinderjit Locham, Ahmed Helal Abdelkarim, Merve Gurakar, Mahmoud B. Malas, Besma Nejim |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Statin Time Factors medicine.drug_class Aortic Diseases Aortoiliac occlusive disease Arterial Occlusive Diseases 030204 cardiovascular system & hematology Logistic regression Iliac Artery Risk Assessment 03 medical and health sciences symbols.namesake 0302 clinical medicine Interquartile range Risk Factors Internal medicine medicine Humans In patient 030212 general & internal medicine Registries Fisher's exact test Aged Retrospective Studies business.industry Perioperative Middle Aged medicine.disease United States Treatment Outcome Propensity score matching symbols Surgery Female Vascular Grafting Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of vascular surgery. 70(2) |
| ISSN: | 1097-6809 |
| Popis: | The benefit of statins in reducing perioperative cardiovascular events in patients undergoing suprainguinal bypass is still controversial. The purpose of this study was to evaluate the association between statin use and perioperative mortality in patients undergoing aortobifemoral bypass (ABFB) for aortoiliac occlusive disease.We retrospectively analyzed all patients who had ABFB in the American College of Surgeons National Surgical Quality Improvement Program data set from 2011 to 2016. Univariable (t-test, χA total of 4445 patients underwent ABFB. Of those, 3032 (68.2%) were taking statins. Compared with nonstatin users, statins users were older (median [interquartile range], 67 years [59-74 years] vs 63 years [56-72 years]; P .01) and more likely to be diabetic (31% vs 16%) and hypertensive (84% vs 63%) and to have a history of chronic obstructive pulmonary disease (20% vs 17%; all P .05). Statin users had lower rates of 30-day mortality (3.4% vs 4.7%; P = .03) and renal complications (2.5% vs 3.7%; P = .04) compared with nonstatin users. After adjustment for patients' demographics (age, sex, race), comorbidities (diabetes, hypertension, congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease, dialysis, bleeding disorder), smoking, clinical presentation (claudication vs critical limb ischemia), and elective surgery status, statin use was associated with 32% reduction in 30-day mortality (odds ratio, 0.68; 95% confidence interval, 0.47-0.96; P = .03). Propensity score matching showed similar results (odds ratio, 0.63; 95% confidence interval, 0.41-0.95; P = .03).This is the largest study to date demonstrating an association between preoperative statin use and lower 30-day mortality after ABFB for aortoiliac occlusive disease. This study highlights an area of potential quality improvement as one-third of the patients undergoing this procedure are not receiving statins. |
| Databáze: | OpenAIRE |
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