Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity
| Autor: | Ion-Hideo Breden, Linn K. Kuehl, Katja Wingenfeld, Christian E. Deuter, André Schulz, Claus Vögele, Christian Otte |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Placebo 050105 experimental psychology Interoception 03 medical and health sciences 0302 clinical medicine Adverse Childhood Experiences Internal medicine Developmental and Educational Psychology medicine Humans 0501 psychology and cognitive sciences Receptor Depressive Disorder Major 05 social sciences Antagonist Yohimbine Drug interaction medicine.disease Receptors Adrenergic Psychiatry and Mental health Endocrinology Blood pressure Major depressive disorder Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Development and Psychopathology. 34:1013-1024 |
| ISSN: | 1469-2198 0954-5794 |
| Popis: | Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamic–pituitary–adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n = 114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (Group × Drug interaction). This effect may be due to selective upregulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE. |
| Databáze: | OpenAIRE |
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