Fetal cervical teratoma: What is the role of fetal MRI in predicting pulmonary hypoplasia?
| Autor: | Mounira Habli, Naira Baregamian, Sundeep G. Keswani, Beth M. Kline-Fath, Foong-Yen Lim, Timothy M. Crombleholme, Ronald Jaekle, Judith Hostiuck, David F. Lewis, David P. Witte, Katherine Wolfe |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Embryology medicine.medical_specialty Gestational Age Cohort Studies Pulmonary hypoplasia Predictive Value of Tests Pregnancy Prenatal Diagnosis Infant Mortality medicine Humans Radiology Nuclear Medicine and imaging Lung volumes Lung Ohio Retrospective Studies Fetus business.industry Infant Newborn Teratoma Obstetrics and Gynecology Gestational age Retrospective cohort study General Medicine Organ Size respiratory system medicine.disease Hospitals Pediatric Magnetic Resonance Imaging Survival Analysis respiratory tract diseases medicine.anatomical_structure Head and Neck Neoplasms Predictive value of tests Pediatrics Perinatology and Child Health Cervical Vertebrae Female Radiology business |
| Zdroj: | Fetal diagnosis and therapy. 33(4) |
| ISSN: | 1421-9964 |
| Popis: | Objective: To determine whether total fetal lung volumes estimated by MRI could predict lethal pulmonary hypoplasia in a cohort of fetuses with cervical teratomas. Methods: We performed a retrospective cohort study of fetal cervical teratomas from January 1, 2005, through April 1, 2012. The primary outcome was the ability of total lung volumes measured by MRI to predict neonatal mortality specifically due to pulmonary hypoplasia. Measured lung volumes were compared to previously reported normal values. The percent of observed-to-expected lung volume and the percent predicted lung volume were calculated. The positive and negative predictive values were calculated for each variable. Results: Fetal MRI-derived total lung volumes 1 standard deviation below the median for gestational age had a positive predictive value of 100% in predicting lethal pulmonary hypoplasia. Conversely, total lung volumes above this level were uniformly associated with pulmonary survival (100% negative predictive value). Additionally, percent predicted lung volume ≤75.7 and observed-to-expected lung volume ≤68.3 were associated with lethal pulmonary hypoplasia. Conclusion: In this small cohort, MRI-estimated lung volumes were helpful in predicting the presence of pulmonary hypoplasia complicating fetal cervical teratoma. |
| Databáze: | OpenAIRE |
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