Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis
| Autor: | Rob J. de Haan, Rob M.A. de Bie, W. Wieling, Daan C. Velseboer, David S. Goldstein |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease business.industry Prevalence Parkinson Disease Disease medicine.disease Autonomic Diseases Article Orthostatic vital signs Study heterogeneity Hypotension Orthostatic Neurology Anesthesia Internal medicine Meta-analysis Unselected population Medicine Humans Neurology (clinical) Geriatrics and Gerontology business |
| Zdroj: | Parkinsonism & related disorders. 17(10):724-729 |
| ISSN: | 1353-8020 |
| Popis: | Background Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson’s disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. Methods From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. Results We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30·1% (95% CI: 22·9% to 38·4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses. Conclusions The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed. |
| Databáze: | OpenAIRE |
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