Potassium-lowering agents for the treatment of nonemergent hyperkalemia: pharmacology, dosing and comparative efficacy
| Autor: | Milisha Shah, Edward F. Foote, Mary Barna Bridgeman |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Hyperkalemia
Potassium chemistry.chemical_element Pharmacology Renin-Angiotensin System chemistry.chemical_compound medicine Humans Dosing Adverse effect Chelating Agents Mineralocorticoid Receptor Antagonists Transplantation Dose-Response Relationship Drug business.industry Silicates Patiromer medicine.disease Treatment Outcome chemistry Nephrology Heart failure Polystyrenes medicine.symptom Sodium Polystyrene Sulfonate business Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 34:iii45-iii50 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfz223 |
| Popis: | Hyperkalemia represents a common and potentially life-threating electrolyte abnormality, a complication frequently observed in patients with heart failure, kidney disease, diabetes or in those receiving drug therapies influencing the renin–angiotensin–aldosterone system. Elevated serum potassium levels are often the result of impaired urinary potassium elimination, inadequate or reduced cellular potassium uptake, severe heart failure, use of medications influencing potassium levels in the circulation, or, more commonly, a combination of these factors. Strategies for the treatment of nonemergent hyperkalemia include the use of cation-exchange resins, polymers or other novel mechanisms of potassium trapping, including sodium polystyrene sulfonate, patiromer and sodium zirconium cyclosilicate. These agents differ in their pharmacology and mechanism of action, clinical efficacy, including onset and extent of potassium-lowering effect, dosage and administration, and potential safety and adverse effect profiles. In this review, an evaluation of these characteristics, including clinical evidence and safety concerns, in the management of nonemergent hyperkalemia will be explored. |
| Databáze: | OpenAIRE |
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