The impacts of intrauterine Bisphenol A exposure on pregnancy and expression of miRNAs related to heart development and diseases in animal model

Autor: Narimah Abdul Hamid Hasani, Rosfaiizah Siran, Zatilfarihiah Rasdi, Syed Baharom Syed Ahmad Fuad, Mohd Hafiz Dzarfan Othman, Roziana Kamaludin, Siti Hamimah Sheikh Abdul Kadir, Sharaniza Ab Rahim, Noor Shafina Mohd Nor
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
endocrine system
Offspring
Physiology
Fluorescent Antibody Technique
lcsh:Medicine
Disease
010501 environmental sciences
01 natural sciences
Biochemistry
Polymerase Chain Reaction
Article
Masson's trichrome stain
Rats
Sprague-Dawley
03 medical and health sciences
Phenols
Fibrosis
Pregnancy
Troponin I
Developmental biology
Medicine
Animals
Benzhydryl Compounds
lcsh:Science
reproductive and urinary physiology
0105 earth and related environmental sciences
Multidisciplinary
Heart development
Molecular medicine
business.industry
urogenital system
Myocardium
Uterus
lcsh:R
Heart
medicine.disease
Rats
Environmental sciences
MicroRNAs
030104 developmental biology
Blood pressure
Liver
Prenatal Exposure Delayed Effects
Female
lcsh:Q
business
hormones
hormone substitutes
and hormone antagonists
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-020-62420-1
Popis: This study aimed to examine the impact of BPA exposure on pregnancy and foetuses on cardiac tissues and the expression of cardiac microRNAs (miRNAs) related to heart development and diseases. Pregnancy is known to be the “critical windows” in determining the offspring physical and cells development in their life after birth. The increment of the risk of cardiovascular disease (CVD) in a later stage of life has been reported by few studies demonstrated from prenatal exposure of BPA. BPA has been shown to alter miRNAs expression profiles for organ development, regeneration and metabolic functions. These alterations have been associated with the risk of CVDs. However, the associations between pregnancy outcomes and miRNAs expression in cardiac of mother- and foetuses-exposed to BPA are still not entirely explored. In BPA-exposed pregnant rat groups, a significant weight gained was observed in comparison to control (p
Databáze: OpenAIRE
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