Augmentation of BNP gene expression in atria by pressure overload in transgenic rats harbouring human renin and angiotensinogen genes
| Autor: | M Luodonpää, O Vuolteenaho, Heikki Ruskoaho, J Puhakka, U Ganten, Minna Marttila |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Angiotensinogen Gene Expression Blood Pressure Animals Genetically Modified Rats Sprague-Dawley Internal medicine Renin–angiotensin system Natriuretic Peptide Brain Renin Internal Medicine medicine Natriuretic peptide Animals Humans cardiovascular diseases Heart Atria RNA Messenger Pressure overload Atrium (architecture) business.industry General Medicine Brain natriuretic peptide Angiotensin II Rats Disease Models Animal medicine.anatomical_structure Endocrinology Blood pressure Ventricle Hypertension cardiovascular system Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor |
| Zdroj: | Blood pressure. 8(5-6) |
| ISSN: | 0803-7051 |
| Popis: | We studied the role of angiotensin II in pressure overload-induced B-type natriuretic peptide (BNP) gene expression by using a double transgenic rat (dTGR) model, in which transgenic rats for the human angiotensinogen and renin genes are crossed. Pressure overload produced by [Arg8]-vasopressin (AVP) infusion (i.v., 0.05 microg/kg/min for 2 h) in conscious, chronically instrumented rats, resulted in a significantly greater increase in BNP mRNA levels in the left atrium of the dTGR rats than in Sprague-Dawley (SD) control rats (3.6- vs 1.6-fold, p < 0.05), while in the left ventricle there was no significant difference between the strains. In dTGR rats, the early activation of the BNP gene expression was associated with a decrease in immunoreactive BNP levels in the atrium (27.5%, p < 0.05), but not in the ventricle. In SD rats, ir-BNP levels did not change significantly in either atria or ventricles in response to AVP infusion. These results show that the pressure overload-induced activation of BNP gene expression differs between atrial and ventricular myocytes in the dTGR model of experimental hypertension. |
| Databáze: | OpenAIRE |
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