Sequential evaluation of left ventricular myocardial performance in children after anthracycline therapy

Autor: Masahiro Ishii, Hirohisa Kato, Kanoko Hashino, Wakako Himeno, Haruhiko Eguchi, Jun Furui, Yoko Sugahara, Genjyu Eto, Takahiro Tsutsumi, Teiji Akagi, Hiromi Muta, Akikazu Ando
Rok vydání: 2000
Předmět:
Zdroj: The American Journal of Cardiology. 86:1279-1281
ISSN: 0002-9149
DOI: 10.1016/s0002-9149(00)01222-4
Popis: The anthracycline antibiotics are important components of many antineoplastic chemotherapeutic regimens. The sequential monitoring of cardiac function of patients undergoing chemotherapy allows the identification of subclinical cardiotoxicity. Such cardiotoxicity is related to the cumulative dose of these drugs; the risk of congestive heart failure in children has been reported to increase at cumulative doses of .550 mg per body surface area. 1,2 To our knowledge, little has been published on the effects of moderate doses of anthracycline antibiotics on left ventricular myocardial performance in clinically asymptomatic children treated for malignant neoplasms. Recently, an easily measured new Doppler index of left ventricular myocardial performance that combines systolic and diastolic time intervals known as the Tei index was proposed. 3,4 This index allows assessment of cardiac “reserve” and enables earlier detection of myocardial dysfunction. It has previously been correlated with severity and clinical outcome in adult 3‐5 and pediatric patients with congenital or acquired heart disease. 6‐ 9 This study prospectively evaluated the Tei index for detecting subclinical cardiotoxicity in patients undergoing chemotherapy. ••• A total of 65 patients were studied while they were receiving anthracycline antibiotic therapy for malignant neoplasms. These subjects were divided into 2 groups (group A, 35 patients who received a low dose (,200 mg/m 2 ) of anthracycline antibiotics; and group B, 30 patients who received a moderate to high dose ($200 mg/m 2 ) of anthracycline antibiotics). None of these patients had received prior mediastinal radiation. A group of 81 age-matched healthy children (age 7.9 6 4.3 years), previously examined in our laboratory, served as a control group. 7 There were no significant differences in age, heart rate, body weight, height, and blood pressure among the 3 groups. Full ethical approval for this study was given by the Kurume University Ethical Committee. We obtained an informed consent from each patient or his or her parents before participation in the study. Echocardiographic examinations were performed
Databáze: OpenAIRE
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