Handling and reporting of orchidectomy specimens with testicular cancer: areas of consensus and variation among 25 experts and 225 European pathologists

Autor:	Jonathan I. Epstein, Rodolfo Montironi, Ferran Algaba, Lars Egevad, Cristina Magi-Galluzzi, Murali Varma, Victor E. Reuter, Eva Comperat, John R. Srigley, Peter A. Humphrey, Clare Verrill, Mahul B. Amin, Daniel M. Berney, Antonio Lopez-Beltran, Esther Oliva, Mohammed Idrees, Robert H. Young, Gregor Mikuz, Brett Delahunt, Thomas M. Ulbright, Kiril Trpkov, Ming Zhou
Rok vydání:	2015
Předmět:	Male medicine.medical_specialty Consensus Histology testis Biology Article Specimen Handling Pathology and Forensic Medicine Vascular invasion Stromal Invasion rete testis Testicular Neoplasms Rete testis Surveys and Questionnaires medicine Humans Neoplasm Invasiveness Expert Testimony Testicular cancer Neoplasm Staging Observer Variation Gynecology Testicular pathology General surgery Tunica vaginalis staging General Medicine Neoplasms Germ Cell and Embryonal medicine.disease Immunohistochemistry Europe medicine.anatomical_structure classification consensus Pagetoid Testicular tumours Orchiectomy germ cell tumour
Zdroj:	HISTOPATHOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname
ISSN:	0309-0167
Popis:	AimsThe handling and reporting of testicular tumours is difficult due to their rarity. Methods and resultsA survey developed by the European Network of Uro-Pathology (ENUP) and sent to its members and experts to assess the evaluation of testicular germ cell tumours. Twenty-five experts and 225 ENUP members replied. Areas of disagreement included immaturity in teratomas, reported by 32% of experts but 68% of ENUP. Although the presence of rete testis invasion was reported widely, the distinction between pagetoid and stromal invasion was made by 96% of experts but only 63% of ENUP. Immunohistochemistry was used in more than 50% of cases by 68% of ENUP and 12% of experts. Staging revealed the greatest areas of disagreement. Invasion of the tunica vaginalis without vascular invasion was interpreted as T1 by 52% of experts and 67% of ENUP, but T2 by the remainder. Tumour invading the hilar adipose tissue adjacent to the epididymis without vascular invasion was interpreted as T1: 40% of experts, 43% of ENUP; T2: 36% of experts, 30% of ENUP; and T3: 24% of experts, 27% of ENUP. ConclusionsThere is remarkable consensus in many areas of testicular pathology. Significant areas of disagreement included staging and reporting of histological types, both of which have the potential to impact on therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699069545e09a99cc44dd2e41ecdfe67 https://doi.org/10.1111/his.12657 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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