Clinical outcomes of autologous cultured oral mucosal epithelium transplantation for treatment of limbal stem cell deficiency
| Autor: | M.Y. Gerasimov, S.A. Borzenok, B.E. Malyugin |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures Keratoprosthesis oral mucosal epithelium Pathogenesis Ophthalmology medicine ocular surface reconstruction Corneal epithelium corneal epithelium business.industry limbal stem cell deficiency RE1-994 medicine.disease eye diseases Transplantation Clinical trial medicine.anatomical_structure Corneal neovascularization sense organs medicine.symptom Complication business transplantation |
| Zdroj: | Офтальмохирургия, Vol 0, Iss 4, Pp 77-85 (2021) |
| ISSN: | 2312-4970 0235-4160 |
| Popis: | The review presents an analysis of clinical trials results for autologous cultured oral mucosal epithelium transplantation (COMET) in patients with bilateral corneal limbal stem cell deficiency (LSCD) over the past 15 years. Detailed characteristics and evaluation are given for anatomical outcomes, visual acuity changes, and complication rates. The results obtained during the analysis confirm the consistency of the concept of corneal re-epithelization by means of COMET. COMET promoted persistent corneal re-epithelization in 81.5% of cases, and visual acuity improvement in 78.8% of patients with LSCD. COMET does not require systemic immunosuppression, and it is accompanied by much smaller numbers and significantly lower grades of complications compared with keratoprosthesis. About 15% of patients experienced developing superficial peripheral corneal neovascularization regressed spontaneously by 12 months of observation. Based on the COMET clinical trials results, the management of patients with bilateral LSCD is under optimization by reference to the pathogenesis of the underlying disease. Thus, autologous cultured oral mucosal epithelium transplantation seems promising for further studies and introduction into routine clinical practice. Key words: limbal stem cell deficiency, ocular surface reconstruction, corneal epithelium, oral mucosal epithelium, transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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