Malignant Leydig cell tumor with spindle-shaped cells in a male CD-1 mouse
| Autor: | Toshinori Yoshida, Takanori Harada, Maki Kuwahara, Yuko Chiba, Mutsumi Kumagai, Yukiko Kashimoto, Satoshi Akema, Naofumi Takahashi, Aya Ohnuma, Nobuaki Nakashima |
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| Rok vydání: | 2010 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Mice Inbred Strains Biology Malignant Leydig cell tumor Rodent Diseases Mice Internal medicine medicine Animals Progenitor cell Actin Cell Nucleus General Veterinary Leydig cell urogenital system Nestin Immunohistochemistry Androgen receptor Endocrinology medicine.anatomical_structure Leydig Cell Tumor Vacuoles Cancer research hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of veterinary medical science. 72(5) |
| ISSN: | 0916-7250 |
| Popis: | Leydig cell tumors with spindle-shaped cells are very rare in humans and animals. We report that an 84-week-old male CD-1 mouse had a malignant Leydig cell tumor characterized by proliferation of oval to spindle-shaped cells with or without fat deposition, and with a storiform pattern. These cells were immunopositive for inhibin and S-100, and negative for the androgen receptor, thereby suggesting that they may have differentiated from Leydig cells. This differentiation from Leydig cells was further confirmed by the immunopositivity of these cells for nestin and alpha-smooth muscle actin, both of which are known to be expressed in the stem/progenitor cells that differentiate into Leydig cells. These findings suggest that the tumor is most probably a malignant spindle-cell-type Leydig cell tumor. |
| Databáze: | OpenAIRE |
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