Identification of CTX-M beta-lactamases in Escherichia coli from hospitalized patients and residents of long-term care facilities
| Autor: | Louise Grenner, Sorana Segal-Maurer, Patricia A. Bradford, James R. Johnson, Noriel Mariano, James J. Rahal, Carl Urban, Wehbeh Wehbeh, Margareta Tuckman, Rita Colon-Urban, Brian D. Johnston |
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| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Male Carbapenem Genotype medicine.drug_class medicine.medical_treatment Antibiotics Drug resistance Microbial Sensitivity Tests Biology beta-Lactam Resistance beta-Lactamases Microbiology Antibiotic resistance Levofloxacin polycyclic compounds medicine Escherichia coli Cluster Analysis Humans Escherichia coli Infections Aged Cross Infection Sulfamethoxazole Escherichia coli Proteins General Medicine biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses Trimethoprim DNA Fingerprinting Long-Term Care Hospitals United States Anti-Bacterial Agents Bacterial Typing Techniques Electrophoresis Gel Pulsed-Field Infectious Diseases Beta-lactamase Female medicine.drug |
| Zdroj: | Diagnostic microbiology and infectious disease. 66(4) |
| ISSN: | 1879-0070 |
| Popis: | Bacteria harboring CTX-M extended-spectrum beta-lactamases (ESBLs) have been identified worldwide, with most reports coming from regions outside North America. We have identified CTX-M enzymes in 31% of ESBL-positive Escherichia coli isolates from our hospital and more than half (53%) of the isolates from associated long-term care facilities. Approximately 3/4 of all CTX-M-bearing isolates were from urine specimens, with a predominance of CTX-M-15. A large proportion of such isolates were nonsusceptible to levofloxacin, trimethoprim/sulfamethoxazole, and all beta-lactam antimicrobials with the exception of the carbapenems, requiring carbapenem therapy for acute urinary tract infection or urinary tract-related sepsis. CTX-M beta-lactamases have emerged within our location, and detection of bacteria harboring these enzymes in the clinical microbiology laboratory remains problematic because molecular methods are needed for their identification. |
| Databáze: | OpenAIRE |
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