Cannabis coadministration potentiates the effects of 'ecstasy' on heart rate and temperature in humans
| Autor: | C Kramers, G.J.H. Dumont, J.M.A. van Gerven, Jan K. Buitelaar, J.G. van Hasselt, Daan J Touw, M. de Kam, Robbert-Jan Verkes, Fred C.G.J. Sweep |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male 110 012 Social cognition of verbal communication Health aging / healthy living [IGMD 5] Epinephrine N-Methyl-3 4-methylenedioxyamphetamine Ecstasy Aetiology screening and detection [ONCOL 5] Pharmacology Mental health [NCEBP 9] 150 000 MR Techniques in Brain Function Body Temperature Norepinephrine Double-Blind Method Heart Rate Translational research [ONCOL 3] Heart rate Cannabinoid receptor type 1 mental disorders Perception and Action [DCN 1] medicine Humans Pharmacology (medical) Dronabinol Psychotropic Drugs Cross-Over Studies Adrenergic Uptake Inhibitors Cardiovascular diseases [NCEBP 14] business.industry organic chemicals Hormonal regulation [IGMD 6] Drug Synergism MDMA Evaluation of complex medical interventions [NCEBP 2] Catecholamine Female business medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics, 86, 160-6 Clinical Pharmacology and Therapeutics, 86, 2, pp. 160-6 |
| ISSN: | 0009-9236 |
| Popis: | Contains fulltext : 80307.pdf (Publisher’s version ) (Closed access) This study assessed the acute physiologic effects over time of (co)administration of Delta9-tetrahydrocannabinol (Delta9-THC) (the main psychoactive compound of cannabis) and 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in 16 healthy volunteers. Pharmacokinetics and cardiovascular, temperature, and catecholamine responses were assessed over time. Both single-drug conditions robustly increased heart rate, and coadministration showed additive effects. MDMA increased epinephrine and norepinephrine concentrations, whereas THC did not affect the catecholamine response. Coadministration of MDMA and THC attenuated the increase of norepinephrine concentrations relative to administration of MDMA alone. These results show that THC mediates heart rate increase independent of sympathetic (catecholaminergic) activity, probably through direct cannabinoid receptor type 1 (CB(1)) agonism in cardiac tissue. Furthermore, THC coadministration did not prevent MDMA-induced temperature increase, but it delayed the onset and prolonged the duration of temperature elevation. These effects may be of particular relevance for the cardiovascular safety of ecstasy users who participate in energetic dancing in nightclubs with high ambient temperature. |
| Databáze: | OpenAIRE |
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