Determination of Piroxicam and Degradation Products in Drugs by TLC
| Autor: | Marek Żylewski, Małgorzata Starek, Monika Tarsa, Jan Krzek |
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| Rok vydání: | 2008 |
| Předmět: |
Chromatography
piroxicam Butylamine Silica gel thin-layer chromatography Organic Chemistry Clinical Biochemistry Ethyl acetate densitometry drug analysis Piroxicam Biochemistry Toluene Thin-layer chromatography Analytical Chemistry chemistry.chemical_compound chemistry Proton NMR medicine Quantitative analysis (chemistry) medicine.drug |
| Zdroj: | Chromatographia. 69:351-356 |
| ISSN: | 1612-1112 0009-5893 |
| Popis: | A thin-layer chromatography method with densitometric detection for the determination of piroxicam and its degradation products is described. Separation was on silica gel TLC plates with ethyl acetate/toluene/butylamine (2+2+1, v/v/v) as the mobile phase. Densitometric detection was carried out at 360 nm. The method has high sensitivity, and satisfactory recovery. Based on 1H NMR and LC–MS–MS, it was found that piroxicam decomposes to produce pyridine-2-amine and 2-methyl-2,3-dihydro-4H-1λ6,2-benzotiazin-1,1,4-trione. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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