In vivo absorption spectroscopy for absolute measurement
| Autor: | Hiromitsu Furukawa, Takashi Fukuda |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty ocis:(300.1030) Absorption Materials science Absorption spectroscopy Scattering Calibration curve Absolute value Atomic and Molecular Physics and Optics Absorbance symbols.namesake ocis:(170.6510) Spectroscopy tissue diagnostics symbols medicine Rayleigh scattering Absorption (electromagnetic radiation) Spectroscopy Spectroscopic Diagnostics Biotechnology Biomedical engineering |
| Zdroj: | ResearcherID Biomedical Optics Express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.3.002587 |
| Popis: | In in vivo spectroscopy, there are differences between individual subjects in parameters such as tissue scattering and sample concentration. We propose a method that can provide the absolute value of a particular substance concentration, independent of these individual differences. Thus, it is not necessary to use the typical statistical calibration curve, which assumes an average level of scattering and an averaged concentration over individual subjects. This method is expected to greatly reduce the difficulties encountered during in vivo measurements. As an example, for in vivo absorption spectroscopy, the method was applied to the reflectance measurement in retinal vessels to monitor their oxygen saturation levels. This method was then validated by applying it to the tissue phantom under a variety of absorbance values and scattering efficiencies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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