Antibody indications of secondary and superimposed retinal hypersensitivity in retinitis pigmentosa
| Autor: | Nancy K. Tyler, John L. Keltner, Charles E. Thirkill, Dolores J. Takemoto, Alan M. Roth |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Radioimmunoassay Enzyme-Linked Immunosorbent Assay Autoantigens Antibodies chemistry.chemical_compound Antigen Retinal Diseases Immunopathology Retinitis pigmentosa medicine Hypersensitivity Humans Photoreceptor Cells Antigens Eye Proteins Retina Gene therapy of the human retina Arrestin business.industry Autoantibody Retinal Middle Aged medicine.disease eye diseases Ophthalmology medicine.anatomical_structure chemistry Immunology Female business Retinitis Pigmentosa Retinopathy |
| Zdroj: | American journal of ophthalmology. 112(2) |
| ISSN: | 0002-9394 |
| Popis: | Antibody reactions with recognized retinopathy-inducing retinal antigens may be interpreted to reflect ongoing autoimmune events responsible for some forms of vision loss. We sought evidence of secondary and superimposed retinal hypersensitivity indicated by such antibody reactivity in a random group of patients with retinitis pigmentosa. We identified patterns of immunologic reactivity within members of a group of 52 patients with retinitis pigmentosa, which suggests some patients with retinitis pigmentosa may experience consequential superimposed retinal hypersensitivity. Identifying subgroups of patients with retinitis pigmentosa who exhibit indications of retinal hypersensitivity to known uveitopathogenic retinal proteins may permit the reduction of their rate of retinal degradation by immunomodulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|