Autoimmune Hepatitis Associated with Pulmonary Arterial Hypertension
| Autor: | Fumihiko Kaneko, Hajime Takeuchi, Tooru Sato, Kenta Hoshi, Hide Yoshida, Toshifumi Hibi, Hiroaki Yokomori, Hirobumi Kondo, Tomochika Takeshita, Kumiko Tahara, Makoto Ohbu |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Cirrhosis medicine.diagnostic_test Anti-nuclear antibody business.industry Hypertension Pulmonary General Medicine Autoimmune hepatitis Middle Aged Pulmonary Artery Tricuspid insufficiency medicine.disease Hepatitis Autoimmune Liver biopsy Internal medicine Internal Medicine medicine Prednisolone Cardiology Humans Portal hypertension Female Liver function business medicine.drug |
| Zdroj: | Internal Medicine. 47:1971-1976 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.47.1420 |
| Popis: | A 46-year-old woman presented with arthralgia. She had a history of fluctuating liver function impairment for 6 months. Laboratory investigations revealed elevated liver function test results, positive antinuclear antibodies and elevated serum IgG. The histological findings of a liver biopsy were interface hepatitis accompanied by plasmocytic infiltration with bridging fibrosis. There was no evidence of cirrhosis on pathological examination and no portal hypertension on endoscopic and radiographic studies. Autoimmune hepatitis was diagnosed, and treatment with prednisolone improved the liver dysfunction. After 6 months, she complained of dyspnea. Doppler echocardiography showed a dilated right ventricle, severe tricuspid insufficiency, and systolic pulmonary arterial pressure indicative of pulmonary arterial hypertension. We report this rare case of autoimmune hepatitis with pulmonary arterial hypertension. |
| Databáze: | OpenAIRE |
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