Influence of Histologic Types and Subtypes on Survival Outcomes of Intermediate-High and High-Risk Renal Cell Carcinoma Following Nephrectomy: Findings From the SEER Database
| Autor: | Adetunji Bakare, Oluwakayode Adejoro, Isaac Oyejinmi, Joshua Ikuemonisan, Adeniyi Togun |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Oncology medicine.medical_specialty Biopsy Urology medicine.medical_treatment Seer database Kaplan-Meier Estimate Chromophobe cell Nephrectomy Risk Assessment Renal cell carcinoma Internal medicine Histologic type medicine Humans Carcinoma Renal Cell Survival analysis Aged Proportional Hazards Models Kidney Proportional hazards model business.industry Middle Aged medicine.disease Kidney Neoplasms Progression-Free Survival United States medicine.anatomical_structure Female business SEER Program |
| Zdroj: | Urology. 159:146-151 |
| ISSN: | 0090-4295 |
| Popis: | To understand the influence of histologic subtypes on the survival outcomes of intermediate-high and high-risk renal cell carcinoma (RCC) following nephrectomy.This study employed data files from the SEER Program to identify patients diagnosed with intermediate-high or high risk RCC and treated with nephrectomy. Unadjusted Kaplan Meier curves, and multivariable Cox regression analyses were applied to estimate the hazards of histologic types for overall survival (OS) and cancer-specific survival (CSS).OS was higher for chromophobe (HR=0.58, 95% CI 0.47-0.70; P.0001), similar for papillary (HR=0.90, 95% CI 0.80-1.02; P=.11) and worse for sarcomatoid (HR=3.17, 95% CI 2.70-3.72; P.0001) subtypes relative to the clear cell subtype. OS was lower in the high-risk disease (HR=2.35, 95% CI 2.01-2.74; P.0001) versus intermediate-high risk disease. CSS was higher for chromophobe (HR=0.47, 95% CI 0.35-0.63; P.0001), similar for papillary (HR=0.91, 95% CI 0.77-1.08; P=.28) and worse for sarcomatoid (HR=4.19, 95% CI 3.50-5.02; P.0001) subtypes relative to the clear cell subtype. CSS was lower for the high-risk disease (HR=2.86, 95%CI 2.39-3.43; P.0001) relative to intermediate-high risk disease. |
| Databáze: | OpenAIRE |
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