Haemorrhagic Effects of Unfractionated and Two Low Molecular Weight Heparins, Enoxaparin and Fragmin, in Rats
| Autor: | C J Bang, Arnold Berstad, Ingebrigt Talstad |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Tail Bleeding Time medicine.drug_class Rat model Low molecular weight heparin Pharmacology Blood loss Bleeding time Physiology (medical) medicine Gastric mucosa Animals Skin Hemostasis medicine.diagnostic_test Heparin business.industry Rats Inbred Strains Hematology Heparin Low-Molecular-Weight Primary haemostasis Rats medicine.anatomical_structure Gastric Mucosa Anesthesia business medicine.drug |
| Zdroj: | Pathophysiology of Haemostasis and Thrombosis. 21:30-36 |
| ISSN: | 1424-8840 1424-8832 |
| DOI: | 10.1159/000216199 |
| Popis: | The effects on primary haemostasis of unfractionated heparin and of the two low molecular weight heparins, enoxaparin and fragmin, were compared in two rat models, one employing the gastric mucosa and the other the tail skin. All three heparin preparations prolonged the bleeding time and increased the blood loss dose dependently. The prolongation of the bleeding time per unit dose caused by unfractionated heparin was significantly greater than the prolongation caused by either one of the two low molecular weight heparins. In the gastric mucosa, but not in the tail skin, enoxaparin prolonged the bleeding time significantly less than fragmin (p < 0.05). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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