Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts
| Autor: | Abdul Wahab, Attiqa Naz, Munair Badshah, Amjad Saeed Khan, Majeed Ullah, Beenish Ali, Hamad S. Alyami |
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| Rok vydání: | 2021 |
| Předmět: |
030226 pharmacology & pharmacy
Polyvinyl alcohol Starches Dosage form Coating Materials chemistry.chemical_compound Hypromellose Derivatives 0302 clinical medicine Magnesium stearate Solubility Materials Fluids Drug Carriers Multidisciplinary Organic Compounds Physics Compression Classical Mechanics Povidone Starch Clopidogrel Solutions Microcrystalline cellulose Chemistry 030220 oncology & carcinogenesis Physical Sciences Medicine Pharmaceutical Vehicles Research Article States of Matter Materials science Science Materials Science Material Properties Carbohydrates Friability Diluent 03 medical and health sciences Cellulose Organic Chemistry Chemical Compounds Liquids chemistry Mixtures Solvents Nuclear chemistry |
| Zdroj: | PLoS ONE, Vol 16, Iss 8 (2021) PLoS ONE PLoS ONE, Vol 16, Iss 8, p e0249075 (2021) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0249075 |
| Popis: | Liquisolid compact is a novel dosage form in which a liquid medication (liquid drug, drug solution/dispersion in non-volatile solvent/solvent system) is converted to a dry, free flowing powder and compressed. Objective of the study was to elucidate the effect of carrier material on release characteristics of clopidogrel from liquisolid compacts. Different formulations of liquisolid compacts were developed using microcrystalline cellulose, starch maize, polyvinyl pyrollidone and hydroxypropyl methylcellulose as carrier material in three concentrations (40, 30 and 20%, w/w). Liquid vehicle was selected on the basis of solubility of clopidogrel. Colloidal silicondioxide was used as coating material and ratio of carrier to coating material was kept 10. A control formulation comprised of microcrystalline cellulose (diluents), tabletose-80 (diluents), primojel (disintegrant) and magnesium stearate (lubricant) was prepared by direct compression technique and was used for comparison. All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and water (2:1, v/v) was selected as liquid vehicle. Drug content was in the range of 99–101% of the claimed quantity. All the formulations showed better mechanical strength and their friability was within the official limits ( |
| Databáze: | OpenAIRE |
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