Utilizing the Natural Composition of Brown Seaweed for the Preparation of Hybrid Ink for 3D Printing of Hydrogels
| Autor: | Kristiina Oksman, Linn Berglund, Fredrik Forsberg, Johan P.E. Junker, Jonathan Rakar |
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| Rok vydání: | 2020 |
| Předmět: |
Inkwell
alginate cellulose nanofibers 3D printing biomimetic hydrogels biomedical application tissue engineering Biochemistry (medical) Biomedical Engineering General Chemistry Polymer Chemistry Biomaterials chemistry.chemical_compound chemistry Chemical engineering Stipe (botany) Brown seaweed Self-healing hydrogels Polymerkemi Composition (visual arts) Cellulose |
| Zdroj: | ACS Applied Bio Materials. 3:6510-6520 |
| ISSN: | 2576-6422 |
| DOI: | 10.1021/acsabm.0c00920 |
| Popis: | This study aims to utilize the natural composition of brown seaweed by deriving alginate and cellulose concurrently from the stipe (stem-like) and blade (leaf-like) structures of the seaweed; further, this is followed by fibrillation for the direct and resource-efficient preparation of alginate/cellulose nanofiber (CNF) hybrid inks for three-dimensional (3D) printing of hydrogels. The efficiency of the fibrillation process was evaluated, and the obtained gels were further studied with regard to their rheological behavior. As a proof of concept, the inks were 3D printed into discs, followed by cross-linking with CaCl2 to form biomimetic hydrogels. It was shown that the nanofibrillation process from both seaweed structures is very energy-efficient, with an energy demand lower than 1.5 kW h/kg, and with CNF dimensions below 15 nm. The inks displayed excellent shear-thinning behavior and cytocompatibility and were successfully printed into 3D discs that, after cross-linking, exhibited an interconnected network structure with favorable mechanical properties, and a cell viability of 71%. The designed 3D biomimetic hydrogels offers an environmentally benign, cost-efficient, and biocompatible material platform with a favorable structure for the development of biomedical devices, such as 3D bio printing of soft tissues. Funding Agencies|Swedish Foundation for Strategic Research within the HEALiX projectSwedish Foundation for Strategic Research [RMX18-0039]; European Regional Development Fund under the Interreg Nord within the Sea -Surf-Snow project [20201287]; Bio4Energy-a strategic research environment |
| Databáze: | OpenAIRE |
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