Evaluation of the effect of a famotidine continuous rate infusion on intragastric pH in healthy dogs
| Autor: | M Katherine Tolbert, Katherine Hedges, Josh Price, Silke Hecht, Adesola Odunayo |
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| Rok vydání: | 2019 |
| Předmět: |
Male
endocrine system acid suppressant 040301 veterinary sciences Intravenous treatment canine Standard Article 030204 cardiovascular system & hematology Beagle Loading dose 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine medicine Animals Monitoring Physiologic Not evaluated lcsh:Veterinary medicine Cross-Over Studies General Veterinary business.industry Critically ill Stomach Gastroenterology histamine‐2 receptor antagonist Gastric Acidity Determination 04 agricultural and veterinary sciences Anti-Ulcer Agents Famotidine Standard Articles Gastric Tissue bravo monitoring Anesthesia lcsh:SF600-1100 Administration Intravenous Female SMALL ANIMAL Analysis of variance business medicine.drug |
| Zdroj: | Journal of Veterinary Internal Medicine Journal of Veterinary Internal Medicine, Vol 33, Iss 5, Pp 1988-1994 (2019) |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | Background Famotidine is sometimes administered as a continuous rate infusion (CRI) to treat gastrointestinal ulceration in critically ill dogs. However, clinical studies have not evaluated the efficacy of a famotidine CRI in dogs. Hypothesis/Objectives To evaluate the efficacy of famotidine at raising intragastric pH when it is administered as a CRI in dogs. We hypothesized that CRI treatment with famotidine would meet clinical goals for raising intragastric pH ≥3 and 4. Animals Nine healthy Beagle dogs. Methods Randomized 2‐way crossover. All dogs received 1.0 mg/kg IV q12h famotidine or CRI famotidine at 1.0 mg/kg IV loading dose and 8.0 mg/kg/d for 3 consecutive days. Beginning on day 0 of treatment, intragastric pH monitoring was used to continuously record intragastric pH. Mean percentage times (MPTs) for which intragastric pH was ≥3 and ≥4 were compared between groups using analysis of variance. Results There was a statistically significant difference (P |
| Databáze: | OpenAIRE |
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