Membrane-embedded TSPO: an NMR view
| Autor: | Stefan Becker, Garima Jaipuria, Andrei Leonov, Markus Zweckstetter, Karin Giller, Gwladys Rivière, Loren B. Andreas |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Magnetic Resonance Spectroscopy Biophysics Membrane biology Solid-state NMR metabolism [Cell Membrane] 03 medical and health sciences 0302 clinical medicine Receptors GABA ddc:570 Translocator protein medicine chemistry [Receptors GABA] Neurodegeneration Lipid bilayer biology Chemistry Endoplasmic reticulum Cell Membrane Structure General Medicine Lipid medicine.disease Transmembrane protein Dynamics Biomarker (cell) Cell biology metabolism [Receptors GABA] Cholesterol 030104 developmental biology Membrane protein biology.protein Original Article TSPO 030217 neurology & neurosurgery |
| Zdroj: | European Biophysics Journal European biophysics journal 50(2), 173-180 (2021). doi:10.1007/s00249-020-01487-0 |
| ISSN: | 1432-1017 0175-7571 |
| DOI: | 10.1007/s00249-020-01487-0 |
| Popis: | Translocator Protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein commonly used as a biomarker for neuroinflammation and is also a potential therapeutic target in neurodegenerative diseases. Despite intensive research efforts, the function of TSPO is still largely enigmatic. Deciphering TSPO structure in the native lipid environment is essential to gain insight into its cellular activities and to design improved diagnostic and therapeutic ligands. Here, we discuss the influence of lipid composition on the structure of mammalian TSPO embedded into lipid bilayers on the basis of solid-state NMR experiments. We further highlight that cholesterol can influence both the tertiary and quaternary TSPO structure and also influence TSPO localization in mitochondria-associated endoplasmic reticulum membranes. |
| Databáze: | OpenAIRE |
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