Aortic aneurysm repair is associated with a lower inflammatory response compared with surgery for inflammatory bowel disease
| Autor: | Lyle L. Moldawer, Sybren L. Meijer, Miguel A. Cuesta, Jan A. Rauwerda, Petra G. Boelens, P.A.M. van Leeuwen, M. P. C. Siroen, Berbel J.R. Sluijter, Jeffrey H. Pruitt, A. H. Naseri, H. S A Oldenburg |
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| Přispěvatelé: | VU University medical center |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Resuscitation medicine.medical_specialty medicine.medical_treatment Inflammation Inflammatory bowel disease Phospholipases A Aortic aneurysm medicine Humans Receptors Tumor Necrosis Factor Type II Postoperative Period Prospective Studies Digestive System Surgical Procedures Aged Haptoglobins business.industry Vascular disease Interleukins Middle Aged Inflammatory Bowel Diseases medicine.disease Ulcerative colitis Abdominal aortic aneurysm Surgery Cytokine Receptors Tumor Necrosis Factor Type I Female medicine.symptom business Vascular Surgical Procedures Aortic Aneurysm Abdominal |
| Zdroj: | Oldenburg, H S A, Siroen, M P C, Boelens, P G, Sluijter, B J R, Pruitt, J H, Naseri, A H, Rauwerda, J A, Meijer, S, Cuesta valentin, M A, van Leeuwen, P A M & Moldawer, L L 2004, ' Aortic aneurysm repair is associated with a lower inflammatory response compared with surgery for inflammatory bowel disease ', European Surgical Research, vol. 36, no. 5, pp. 266-273 . https://doi.org/10.1159/000079911 European Surgical Research, 36(5), 266-273. S. Karger AG |
| ISSN: | 0014-312X |
| DOI: | 10.1159/000079911 |
| Popis: | Background: Since the plasma cytokine profile reflects the body’s inflammatory response to injury, this study was designed to prospectively observe the plasma cytokine levels in response to the degree of different sorts of abdominal surgical trauma. Methods: Plasma levels of TNF-α, type I TNF receptor (p55), type II TNF receptor (p75), IL-6, IL-8, IL-10, phospholipase A2 (PLA2), and haptoglobin were measured peri-operatively in patients undergoing bowel resection for inflammatory bowel disease or diverticulitis (IBD) (n = 9), elective repair of abdominal aortic aneurysm (AAA) (n = 9), or laparoscopic cholecystectomy (lap chole) (n = 9). Results: The IBD patients showed a significant (p < 0.05) post-operative elevation in plasma IL-6, p55, p75, and PLA2 levels, but no significant change in TNF-α, IL-8, IL-10 or haptoglobin levels. The AAA patients had a significant post-operative rise in IL-10 levels and a significant decrease in plasma haptoglobin levels, but no significant change of TNF-α, IL-6, IL-8, p55, p75, or PLA2 concentrations. The lap chole patients demonstrated no significant change in any of these parameters. Conclusion: These data show that IL-6, IL-10, p55, and p75 are markers to measure the degree of inflammatory stress associated with abdominal operative procedures and demonstrate the relative lack of a cytokine response to laparoscopic cholecystectomy. |
| Databáze: | OpenAIRE |
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