Comparison of atenolol with propranolol in the treatment of angina pectoris with special reference to once daily administration of atenolol
| Autor: | J D Harry, David E. Jewitt, Graham Jackson, D Kitson, C Robinson |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood Pressure Propranolol Placebo Drug Administration Schedule Angina Pectoris Propanolamines Angina Nitroglycerin Random Allocation Double-Blind Method Heart Rate Internal medicine Heart rate Humans Medicine cardiovascular diseases Clinical Trials as Topic business.industry Middle Aged Atenolol medicine.disease Clinical trial Blood pressure Anesthesia Ambulatory Exercise Test Cardiology Female Cardiology and Cardiovascular Medicine business Research Article circulatory and respiratory physiology medicine.drug |
| Zdroj: | Heart. 40:998-1004 |
| ISSN: | 1355-6037 |
| DOI: | 10.1136/hrt.40.9.998 |
| Popis: | Fourteen patients with angina pectoris completed a double blind trial of atenolol 25 mg, 50 mg, and 100 mg twice daily and propranolol 80 mg thrice daily. In comparison with placebo, all active treatments significantly reduced anginal attacks, consumption of glyceryl trinitrate, resting and exercise heart rate, resting and exercise systolic blood pressure, and significantly prolonged exercise time. There was no significant difference between the effects of propranolol and atenolol. Nine patients completed a further trial comparing atenolol given once or twice daily. Both regimens were effective and there was no significant difference between the reductions in anginal attacks, glyceryl trinitrate consumption, systolic blood pressure, or heart rate. Twenty-four-hour ambulatory electrocardiograms showed that atenolol consistently reduced heart rate throughout the 24-hour period whether given once or twice daily. Atenolol is a potent antianginal agent which, in most patients, is likely to be effective once daily. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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