The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
| Autor: | Luis González-Feria, Arkaitz Carracedo, Valentin Giroux, Cédric Malicet, Miguel A. Piris, Stéphane Garcia, Juan L. Iovanna, Mar Lorente, Manuel Guzmán, Cristina Blázquez, Guillermo Velasco, Raquel Villuendas, Meritxell Gironella, Ainara Egia |
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| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Ceramide Biopsy medicine.medical_treatment Apoptosis Cell Cycle Proteins CELLCYCLE Protein Serine-Threonine Kinases Biology Endoplasmic Reticulum Mice chemistry.chemical_compound Mediator Downregulation and upregulation Neoplasms Basic Helix-Loop-Helix Transcription Factors Tumor Cells Cultured medicine Animals Humans Dronabinol Cannabinoids Endoplasmic reticulum Cell Biology DNA Cell cycle Activating Transcription Factor 4 Xenograft Model Antitumor Assays Neoplasm Proteins Up-Regulation Cell biology Gene Expression Regulation Neoplastic Repressor Proteins Oncology chemistry Cannabinoid Signal transduction Glioblastoma Transcription Factor CHOP Signal Transduction |
| Zdroj: | Cancer Cell. 9:301-312 |
| ISSN: | 1535-6108 |
| Popis: | SummaryOne of the most exciting areas of current research in the cannabinoid field is the study of the potential application of these compounds as antitumoral drugs. Here, we describe the signaling pathway that mediates cannabinoid-induced apoptosis of tumor cells. By using a wide array of experimental approaches, we identify the stress-regulated protein p8 (also designated as candidate of metastasis 1) as an essential mediator of cannabinoid antitumoral action and show that p8 upregulation is dependent on de novo-synthesized ceramide. We also observe that p8 mediates its apoptotic effect via upregulation of the endoplasmic reticulum stress-related genes ATF-4, CHOP, and TRB3. Activation of this pathway may constitute a potential therapeutic strategy for inhibiting tumor growth. |
| Databáze: | OpenAIRE |
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