FDG-PET Imaging for Oxidized LDL in Stable Atherosclerotic Disease: A Phase II Study of Safety, Tolerability, and Anti-Inflammatory Activity

Autor:	Zahi A. Fayad, Amr Abdelbaky, Jill Fredrickson, Parmanand Singh, Brian B. Ghoshhajra, Magnus Korsgren, Michael Koren, Daniel Duprez, Eli M. Roth, Amos Baruch, Christie M. Ballantyne, Nick Van Bruggen, Esad Vucic, Joshua E. Lehrer-Graiwer, Frank Hsieh, Ahmed Tawakol, Robert S. Rosenson, James H.F. Rudd, Meina T. Tang, Björn Frendéus
Jazyk:	angličtina
Předmět:	biology medicine.drug_class business.industry Atherosclerotic disease Phases of clinical research Anti-inflammatory 3. Good health Mediator Radiology Nuclear Medicine and imaging Monoclonal Immunology biology.protein Cancer research medicine lipids (amino acids peptides and proteins) Radiology Nuclear Medicine and imaging Antibody Cardiology and Cardiovascular Medicine business Oxidized ldl Lipoprotein
Zdroj:	JACC: Cardiovascular Imaging. (4):493-494
ISSN:	1936-878X
DOI:	10.1016/j.jcmg.2014.06.021
Popis:	Previous reports have demonstrated that oxidized low-density lipoprotein (oxLDL) is a key mediator in atherogenesis [(1)][1]. oxLDL increases endothelial cell adhesion molecules, recruitment of inflammatory cells into the vessel wall, and formation of foam cells, all hallmarks of atherosclerosis
Databáze:	OpenAIRE
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