Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease
| Autor: | Audrey Gabelle, Karen Ritchie, Marie-Laure Ancelin, Sylvaine Artero, Philippe Courtet, Claudine Berr, Mélissa Gentreau, Chantal Meslin, Thibault Mura, Jerome Joseph Maller, Fabienne Cyprien |
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| Přispěvatelé: | Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Monash Alfred Psychiatry Research Centre (MAPrc), The Alfred & Monash University School of Psychology and Psychiatry, Australian National University (ANU), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), University of Edinburgh |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
[SDV]Life Sciences [q-bio] Grey matter Corpus callosum Cerebral white matter corpus callosum 03 medical and health sciences 0302 clinical medicine Neuroimaging Alzheimer Disease Internal medicine medicine Dementia Risk factor Applied Psychology medicine.diagnostic_test business.industry Magnetic resonance imaging cohort medicine.disease Hyperintensity 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure risk factor Cardiology [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Alzheimer's disease business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology 030217 neurology & neurosurgery Personality |
| Zdroj: | Psychological Medicine Psychological Medicine, Cambridge University Press (CUP), 2021, 14, pp.1-10. ⟨10.1017/S0033291721000416⟩ |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundCynical hostility (CH), a specific dimension of hostility that consists of a mistrust of others, has been suggested as a high-risk trait for dementia. However, the influence of CH on the incidence of Alzheimer's disease (AD) remains poorly understood. This study investigated whether late-life CH is associated with AD risk and structural neuroimaging markers of AD.MethodsIn community-dwelling older adults from the French ESPRIT cohort (n = 1388), incident dementia rate according to CH level was monitored during an 8-year follow-up and analyzed using Cox proportional hazards regression models. Brain magnetic resonance imaging volumes were measured at baseline (n = 508). Using automated segmentation procedures (Freesurfer 6.0), the authors assessed brain grey and white volumes on all magnetic resonance imaging scans. They also measured white matter hyperintensities volumes using semi-automated procedures. Mean volumes according to the level of CH were compared using ANOVA.ResultsEighty-four participants developed dementia (32 with AD). After controlling for potential confounders, high CH was predictive of AD (HR 2.74; 95% CI 1.10–6.85; p = 0.030) and all dementia types are taken together (HR 2.30; 95% CI 1.10–4.80; p = 0.027). High CH was associated with white matter alterations, particularly smaller anterior corpus callosum volume (p < 0.01) after False Discovery Rate correction, but not with grey matter volumes.ConclusionsHigh CH in late life is associated with cerebral white matter alterations, designated as early markers of dementia, and higher AD risk. Identifying lifestyle and biological determinants related to CH could provide clues on AD physiopathology and avenues for prevention strategies. |
| Databáze: | OpenAIRE |
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