| Autor: |
Kate G. E. Bradford, Xiaojun Zeng, Zhi Cao, Tzu Hsuan Chao, Tung Chun Kuo, Samson B. Zacate, Wei Liu, Mu Jeng Cheng, Matthew Paeth, Wenhao Yan, Kundi Yang, Xiaodong Sun, Sam B. Tyndall |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of the American Chemical Society. 141(29) |
| ISSN: |
1520-5126 |
| Popis: |
We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-containing complex molecules to the alkyl-CF2H products. Mechanistic studies support the involvement of alkyl radicals. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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