The role of pharmacogenomics in adverse drug reactions
| Autor: | Natalia Cacabelos, Ramón Cacabelos, Juan C. Carril |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Drug Industry Drug-Related Side Effects and Adverse Reactions business.industry General Medicine 030226 pharmacology & pharmacy White People Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Drug Development Pharmaceutical Preparations Pharmacogenetics 030220 oncology & carcinogenesis Pharmacogenomics Practice Guidelines as Topic medicine Humans Pharmacology (medical) Drug reaction Practice Patterns Physicians' General Pharmacology Toxicology and Pharmaceutics Intensive care medicine business Drug Labeling |
| Zdroj: | Expert Review of Clinical Pharmacology. 12:407-442 |
| ISSN: | 1751-2441 1751-2433 |
| DOI: | 10.1080/17512433.2019.1597706 |
| Popis: | Adverse drug reactions (ADRs) are a major health concern worldwide. There are multiple causes of ADRs, some of which are preventable. Pharmacogenomics accounts for ≈80% variability in drug efficacy and safety. Over 400 genes are clinically relevant in drug metabolism, and ≈200 pharmagenes are associated with ADRs. The condition of extensive metabolizer in the Caucasian population is lower than 20%, and about 60% of patients are exposed to potential ADRs. Areas covered: Important topics related to pharmacogenomics in drug efficacy and safety are covered, including: (i) major components of the pharmacogenomic machinery; (ii) epigenetic regulation of pharmagene expression; and (iii) pharmacogenomics-related ADRs of different drug categories. Expert opinion: The Regulatory Agencies should make recommendations to the pharmaceutical industry in favor of the introduction of pharmacogenomics in drug development and the inclusion of pharmacogenomic information on drug labels, with specific warnings for the population at risk. Educational programs are fundamental for drug prescribers to become familiar with personalized treatments. Pharmacogenetic testing should be gradually introduced into medical practice. ADRs can be reduced not only by adherence to prescribing guidelines, suitable monitoring and regular medication review, but also by the implementation of pharmacogenomic procedures in the clinical setting. |
| Databáze: | OpenAIRE |
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