Distinct Neuroanatomical Correlates of Neuropsychiatric Symptoms in the Three Main Forms of Genetic Frontotemporal Dementia in the GENFI Cohort

Autor: Leila Sellami, Maria Carmela Tartaglia, John C. van Swieten, Giovanni B. Frisoni, Genfi Genetic Ftd Initiative, Alexandre de Mendonça, Jason D. Warren, Mario Masellis, Sandro Sorbi, James B. Rowe, E Finger, Fabrizio Tagliavini, Martina Bocchetta, Robert Laforce, Caroline Graff, Barbara Borroni, Katrina M. Dick, David M. Cash, Daniela Galimberti, Jonathan D. Rohrer
Přispěvatelé: Neurology
Rok vydání: 2018
Předmět:
Adult
Male
0301 basic medicine
tau Proteins
Grey matter
Neuropsychiatry
Temporal lobe
Cohort Studies
03 medical and health sciences
Progranulins
0302 clinical medicine
Atrophy
C9orf72
Frontal cortical atrophy
mental disorders
medicine
Humans
magnetic resonance imaging
genetics
neuropsychiatry
Aged
C9orf72 Protein
business.industry
General Neuroscience
Brain
nutritional and metabolic diseases
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
nervous system diseases
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
medicine.anatomical_structure
Psychotic Disorders
Frontotemporal Dementia
Mutation
ddc:618.97
Female
Cerebellar atrophy
Geriatrics and Gerontology
business
Neuroscience
030217 neurology & neurosurgery
Frontotemporal dementia
Research Article
Zdroj: Journal of Alzheimers Disease, 65(1), 147-163. IOS Press BV
Journal of Alzheimer's Disease, Vol. 65, No 1 (2018) pp. 147-163
Journal of Alzheimer's Disease
ISSN: 1875-8908
1387-2877
Popis: Background: The overlap between frontotemporal dementia (FTD) and primary psychiatric disorders has been brought to light by reports of prominent neuropsychiatric symptoms (NPS) in FTD-related genetic mutations, particularly among C9orf72 and GRN carriers. It has been recently demonstrated that early neuroanatomical changes in genetic FTD may be different across the major disease-causing mutations. // Objective: We aimed to identify whether NPS could be driven by distinct structural correlates. // Methods: One hundred and sixty-seven mutation carriers (75 GRN, 60 C9orf72, and 32 MAPT) were included from the Genetic FTD Initiative (GENFI) study, a large international cohort of genetic FTD. Neuropsychiatric symptoms including delusions, hallucinations (visual, auditory, and tactile), depression, and anxiety were investigated using a structured interview. Voxel-based morphometry was performed to identify neuroanatomical correlates of NPS. // Results: Psychotic symptoms correlated mainly with grey matter (GM) atrophy in the anterior insula, left thalamus, cerebellum, and cortical regions including frontal, parietal, and occipital lobes in GRN mutations carriers. GM atrophy in posterior structures of the default-mode network was associated with anxiety in the GRN group. Delusions in C9orf72 expansion carriers were mainly associated with left frontal cortical atrophy. Cerebellar atrophy was found to be correlated only with anxiety in C9orf72 carriers. NPS in the MAPT group were mainly associated with volume loss in the temporal lobe. // Conclusion: Neuroanatomical correlates of NPS appear to be distinct across the main forms of genetic FTD. Overall, our findings support overlapping brain structural changes between FTD and primary psychiatric disorders.
Databáze: OpenAIRE
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