Distinct Neuroanatomical Correlates of Neuropsychiatric Symptoms in the Three Main Forms of Genetic Frontotemporal Dementia in the GENFI Cohort
Autor: | Leila Sellami, Maria Carmela Tartaglia, John C. van Swieten, Giovanni B. Frisoni, Genfi Genetic Ftd Initiative, Alexandre de Mendonça, Jason D. Warren, Mario Masellis, Sandro Sorbi, James B. Rowe, E Finger, Fabrizio Tagliavini, Martina Bocchetta, Robert Laforce, Caroline Graff, Barbara Borroni, Katrina M. Dick, David M. Cash, Daniela Galimberti, Jonathan D. Rohrer |
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Přispěvatelé: | Neurology |
Rok vydání: | 2018 |
Předmět: |
Adult
Male 0301 basic medicine tau Proteins Grey matter Neuropsychiatry Temporal lobe Cohort Studies 03 medical and health sciences Progranulins 0302 clinical medicine Atrophy C9orf72 Frontal cortical atrophy mental disorders medicine Humans magnetic resonance imaging genetics neuropsychiatry Aged C9orf72 Protein business.industry General Neuroscience Brain nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases Psychiatry and Mental health Clinical Psychology 030104 developmental biology medicine.anatomical_structure Psychotic Disorders Frontotemporal Dementia Mutation ddc:618.97 Female Cerebellar atrophy Geriatrics and Gerontology business Neuroscience 030217 neurology & neurosurgery Frontotemporal dementia Research Article |
Zdroj: | Journal of Alzheimers Disease, 65(1), 147-163. IOS Press BV Journal of Alzheimer's Disease, Vol. 65, No 1 (2018) pp. 147-163 Journal of Alzheimer's Disease |
ISSN: | 1875-8908 1387-2877 |
Popis: | Background: The overlap between frontotemporal dementia (FTD) and primary psychiatric disorders has been brought to light by reports of prominent neuropsychiatric symptoms (NPS) in FTD-related genetic mutations, particularly among C9orf72 and GRN carriers. It has been recently demonstrated that early neuroanatomical changes in genetic FTD may be different across the major disease-causing mutations. // Objective: We aimed to identify whether NPS could be driven by distinct structural correlates. // Methods: One hundred and sixty-seven mutation carriers (75 GRN, 60 C9orf72, and 32 MAPT) were included from the Genetic FTD Initiative (GENFI) study, a large international cohort of genetic FTD. Neuropsychiatric symptoms including delusions, hallucinations (visual, auditory, and tactile), depression, and anxiety were investigated using a structured interview. Voxel-based morphometry was performed to identify neuroanatomical correlates of NPS. // Results: Psychotic symptoms correlated mainly with grey matter (GM) atrophy in the anterior insula, left thalamus, cerebellum, and cortical regions including frontal, parietal, and occipital lobes in GRN mutations carriers. GM atrophy in posterior structures of the default-mode network was associated with anxiety in the GRN group. Delusions in C9orf72 expansion carriers were mainly associated with left frontal cortical atrophy. Cerebellar atrophy was found to be correlated only with anxiety in C9orf72 carriers. NPS in the MAPT group were mainly associated with volume loss in the temporal lobe. // Conclusion: Neuroanatomical correlates of NPS appear to be distinct across the main forms of genetic FTD. Overall, our findings support overlapping brain structural changes between FTD and primary psychiatric disorders. |
Databáze: | OpenAIRE |
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