Encephalopathy After Whole-Cell Pertussis or Measles Vaccination
| Autor: | David Michelson, Paula Ray, Ken Huff, Robert F. Davis, Steve Black, Robert T. Chen, Jean C. Hayward, Henry R. Shinefield, Joan Schwalbe, Joel I. Ward, Edwin Lewis, Michael Marcy, John P. Mullooly |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Microbiology (medical) Pediatrics medicine.medical_specialty Encephalopathy Disease Measles medicine Humans Child Diphtheria-Tetanus-Pertussis Vaccine Whooping cough Retrospective Studies Brain Diseases business.industry Infant Newborn Case-control study Infant medicine.disease Vaccination Infectious Diseases Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Immunology Encephalitis Female Viral disease business Measles-Mumps-Rubella Vaccine |
| Zdroj: | Pediatric Infectious Disease Journal. 25:768-773 |
| ISSN: | 0891-3668 |
| Popis: | Whole-cell pertussis (wP) and measles vaccines are effective in preventing disease but have also been suspected of increasing the risk of encephalopathy or encephalitis. Although many countries now use acellular pertussis vaccines, wP vaccine is still widely used in the developing world. It is therefore important to evaluate whether wP vaccine increases the risk of neurologic disorders.A retrospective case-control study was performed at 4 health maintenance organizations. Records from January 1, 1981, through December 31, 1995, were examined to identify children aged 0 to 6 years old hospitalized with encephalopathy or related conditions. The cause of the encephalopathy was categorized as known, unknown or suspected but unconfirmed. Up to 3 controls were matched to each case. Conditional logistic regression was used to analyze the relative risk of encephalopathy after vaccination with diphtheria-tetanus-pertussis (DTP) or measles-mumps-rubella (MMR) vaccines in the 90 days before disease onset as defined by chart review compared with an equivalent period among controls indexed by matching on case onset date.Four-hundred fifty-two cases were identified. Cases were no more likely than controls to have received either vaccine during the 90 days before disease onset. When encephalopathies of known etiology were excluded, the odds ratio for case children having received DTP within 7 days before onset of disease was 1.22 (95% confidence interval [CI] = 0.45-3.31, P = 0.693) compared with control children. For MMR in the 90 days before onset of encephalopathy, the odds ratio was 1.23 (95% confidence interval = 0.51-2.98, P = 0.647).In this study of more than 2 million children, DTP and MMR vaccines were not associated with an increased risk of encephalopathy after vaccination. |
| Databáze: | OpenAIRE |
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