High-dose depot-medroxyprogesterone acetate (DMPA) — effects on lipid and lipoprotein metabolism
| Autor: | Göran Samsioe, A. Skryten, L. Enk, G. Silfverstolpe, N. Crona |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Medroxyprogesterone
medicine.medical_specialty Very low-density lipoprotein Lipoproteins Antineoplastic Agents Medroxyprogesterone Acetate Lipoproteins VLDL Carbohydrate metabolism chemistry.chemical_compound Internal medicine medicine Humans Medroxyprogesterone acetate Phospholipids Triglycerides Aged Triglyceride Cholesterol business.industry nutritional and metabolic diseases Obstetrics and Gynecology Lipid metabolism Middle Aged Lipid Metabolism Lipoproteins LDL Endocrinology Reproductive Medicine chemistry Uterine Neoplasms Female lipids (amino acids peptides and proteins) Lipoproteins HDL business medicine.drug Lipoprotein |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 16:97-105 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/0028-2243(83)90106-5 |
| Popis: | Twenty-one women were given depot-medroxyprogesterone acetate (DMPA) 1000 mg/wk for 6 mth as part of the treatment for endometrial carcinoma in either clinical stage I or II. Total and free cholesterol, triglycerides and phospholipids were analysed in serum and in the ultracentrifugally separated lipoprotein fractions VLDL, LDL and HDL (very low, low and high density lipoproteins). Previous studies have shown little effect on lipoprotein metabolism after lower doses of MPA, unlike progestins of the 19-nor-testosterone series, after which an 'androgenic' lipoprotein pattern is seen, i.e., a decrease in HDL-cholesterol and in triglycerides in serum and VLDL. After this massive DMPA dose, only a slight decrease in HDL-cholesterol was seen, as well as a rise in triglycerides in serum and VLDL. We interpret the latter finding as secondary to an influence on carbohydrate metabolism. |
| Databáze: | OpenAIRE |
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