Postabsorptive muscle protein metabolism in type 1 diabetic patients after pancreas transplantation
| Autor: | Livio Luzi, V. Di Carlo, Guido Pozza, M. Spessot, L. Piceni Sereni, M. R. Pastore, Ileana Terruzzi, Antonio Secchi, M. Bianchi, R. Dodesini, M. Cristallo |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Phenylalanine Endocrinology Diabetes and Metabolism medicine.medical_treatment Protein metabolism Muscle Proteins Pancreas transplantation Protein degradation chemistry.chemical_compound Endocrinology Leucine Reference Values Internal medicine Diabetes mellitus Internal Medicine medicine Hyperinsulinemia Humans Insulin Muscle Skeletal Glycated Hemoglobin Type 1 diabetes C-Peptide business.industry Proteins General Medicine Middle Aged medicine.disease Transplantation Forearm Diabetes Mellitus Type 1 chemistry Regional Blood Flow Protein Biosynthesis Cyclosporine Prednisone Pancreas Transplantation Energy Intake business Immunosuppressive Agents |
| Zdroj: | Acta Diabetologica. 37:219-224 |
| ISSN: | 1432-5233 0940-5429 |
| DOI: | 10.1007/s005920070009 |
| Popis: | Insulin was shown to induce protein anabolism in vivo mainly by inhibiting proteolysis. Heterotopic pancreas transplantation in type 1 diabetes mellitus is characterized by peripheral hyperinsulinemia due to systemic rather than portal insulin delivery. Therefore, we studied the postabsorptive muscle protein metabolism in type 1 diabetic patients with or without pancreas transplantation. The forearm balance technique was performed in 9 type 1 diabetic patients on exogenous insulin treatment, in 4 type 1 diabetic patients following successful pancreas transplantation and in 6 healthy volunteers. Labelled leucine and phenylalanine were infused to quantify whole-body and muscle protein synthesis, respectively. In the postabsorptive state, whole-body protein synthesis (leucine kinetics) was similar in pancreas-transplanted patients and controls. In contrast, muscle protein synthesis tended to be less negative in pancreas-transplanted patients with respect to type 1 diabetic patients and healthy volunteers. The present data suggest that recipients with peripheral insulin delivery and chronic hyperinsulinemia are characterized by a preferential stimulation of protein synthesis in muscle rather than in the splanchnic district. When insulin was infused acutely, while maintaining euglycemia, the whole-body and muscle protein synthesis rates were approximately halved in type 1 diabetic patients with and without pancreas transplantation. We conclude that pancreas transplantation is able to normalize basal and insulin-stimulated protein metabolism. Chronic hyperinsulinemia counteract steroid-induced protein degradation by means of a mild, but persistent stimulation of muscle protein synthesis. |
| Databáze: | OpenAIRE |
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