Effects of stimulated repopulation on oral mucositis during conventional radiotherapy
| Autor: | Th. Herrmann, A. Jacubek, U. Eckelt, J. Kummermehr, Wolfgang Dörr, I. Dölling-Jochem |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology medicine.medical_treatment Urology Cell Count Stimulation chemistry.chemical_compound Conventional radiotherapy medicine Mucositis Humans Radiology Nuclear Medicine and imaging Oral mucosa Aged Aged 80 and over Stomatitis business.industry Mouth Mucosa Hematology Middle Aged medicine.disease Radiation therapy Silver nitrate medicine.anatomical_structure Oncology chemistry Head and Neck Neoplasms Total dose Carcinoma Squamous Cell Silver Nitrate Female Repopulation business Cell Division |
| Zdroj: | Radiotherapy and Oncology. 37:100-107 |
| ISSN: | 0167-8140 |
| Popis: | The effect of local conditioning of human oral mucosa by silver nitrate solution (3%) on epithelial proliferation rates was tested in 11 healthy volunteers by in vitro labelling of biopsies with tritiated thymidine. Compared to control biopsies from 13 volunteers, stimulation over 3 days, 3 times per day, yielded a significant ( p = 0.006) increase in the epithelial labelling index (LI) from 4.75 ± 0.32% to 6.85 ± 0.65%, i.e., by 44%. The increase in the absolute number of labelled cells per mm epithelial length was dependent on the overall cell density at the various intraoral sites and varied between 45% in the maxillary vestibule and 91% at the floor of the mouth. In an analysis of variance, stimulation turned out to be the most important source causing the effect ( p = 0.011 for LI and 0.015 for labelled cells per mm). In a radiotherapy trial with conventional postoperative treatment with 5 × 2 Gy/week to a total dose of 60 Gy in 6 weeks, the left buccal mucosa in 10 patients with squamous cell carcinomas of the head and neck was conditioned (3% silver nitrate, 3 times per day, 5 days before and the first 2 days of radiotherapy) while the contralateral mucosa, receiving an identical dose, served as individual control. Mucositis scores according to the EORTC/RTOG or the Dische system showed that the time course and severity of the mucosal response was almost identical in both cheeks, which is in clear contrast to a previous clinical study (Maciejewski et al. Radiother. Oncol. 22, 7–11, 1991). Differences in radiation dose intensity, i.e., weekly dose, in these studies are discussed as a tentative explanation for the different clinical findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect