Extrapyramidal side-effects and dopamine D2/3receptor binding in substantia nigra

Autor:	Minna Husso, Heimo Viinamäki, Jyrki T. Kuikka, Heli Tuppurainen, Jari Tiihonen
Rok vydání:	2010
Předmět:	Adult Male Olanzapine medicine.medical_specialty Substantia nigra Magnetic Resonance Imaging Interventional Benzodiazepines Extrapyramidal symptoms Dopamine receptor D3 Dopamine Dopamine receptor D2 medicine Haloperidol Humans Psychiatry Clozapine Tomography Emission-Computed Single-Photon Temporal cortex Brain Mapping Receptors Dopamine D2 business.industry Receptors Dopamine D3 Substantia Nigra Psychiatry and Mental health Schizophrenia Female medicine.symptom business Antipsychotic Agents medicine.drug
Zdroj:	Nordic Journal of Psychiatry. 64:233-238
ISSN:	1502-4725 0803-9488
Popis:	The exact mechanisms for antipsychotic-induced extrapyramidal side-effects have remained obscure despite intensive research. Previous studies have highlighted a central role for nigral dopamine D(2) receptors in the control of motor functions.The aim of the present study was to examine relationships between dopamine D(2) receptor binding in both substantia nigra and temporal cortex with extrapyramidal symptoms among antipsychotic-treated patients with schizophrenia.Single-photon emission-computed tomography (SPECT) ligand [(123)I]epidepride was used to determine dopamine D(2/3) apparent binding potential in 13 antipsychotic-treated (seven with clozapine, four with olanzapine and two with haloperidol) patients with schizophrenia. Extrapyramidal symptoms were assessed with the Simpson and Angus Scale (SAS).A statistically significant correlation was observed between dopamine D(2/3) receptor apparent binding potential in the substantia nigra and extrapyramidal side-effects (r = -0.62, P = 0.024). No correlations were detected in the temporal cortex between dopamine D(2/3) receptor binding and extrapyramidal side-effects.These findings support the role of dopamine D(2) autoreceptors in substantia nigra regarding drug-induced movement disorders.
Databáze:	OpenAIRE
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