In vivo oxidized low-density lipoprotein (ox-LDL) aopp and tas after kidney transplantation: a prospective, randomized one year study comparing cyclosporine A and tacrolimus based regiments
| Autor: | Jitka Vostálová, Petr Schneiderka, Jana Zapletalová, Pavel Štrebl, Josef Zadrazil, Karel Krejčí, Adéla Galandáková, Pavel Horák, Helena Vaverkova, Markéta Kajabová |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Calcineurin Inhibitors Renal function medicine.disease_cause Gastroenterology General Biochemistry Genetics and Molecular Biology Antioxidants Tacrolimus chemistry.chemical_compound Internal medicine Cyclosporin a medicine Humans Kidney transplantation Creatinine business.industry Blood Proteins Middle Aged medicine.disease Kidney Transplantation Calcineurin Lipoproteins LDL Oxidative Stress Endocrinology chemistry Advanced oxidation protein products Cyclosporine Female business Oxidation-Reduction Oxidative stress Immunosuppressive Agents |
| Zdroj: | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 156(1) |
| ISSN: | 1804-7521 |
| Popis: | Aims. Restoration of renal function after kidney transplantation (KT) is expected to improve oxidative stress (OS). However, little is known about the influence of calcineurin inhibitors on oxidized low-density lipoproteins (ox-LDL) after KT. The aim of this study was to evaluate ox-LDLs and related markers of OS, advanced oxidation protein products (AOPP) and total antioxidant status (TAS) in patients after KT on either cyclosporin A (CyA) or tacrolimus (Tac) treatment. Methods. This was a prospective, randomized, single-center 12 month study evaluating time-dependent changes in biomarkers of OS before and after KT. Twenty nine patients (mean age 54.4 ± 11.1; 55% male and 45% female) were treated with CyA (Group A) and twenty four patients (mean age 52.9 ± 9.9; 75% male and 25% female) were treated with Tac (Group B). The ox-LDL, AOPP, TAS, lipid metabolism parameters, creatinine and glomerular filtration were assessed on day 1 before KT and on days 1 and 7, and in months 1, 3, 6 and 12 after KT. Results. Over the 12 months, the ox-LDL for group A changed from 69.2±32.9 to 65.1±17.1 U/L (P=0.665), while AOPP significantly decreased from 233.0±159.6 to 156.5±90.1 μmol/L (P=0.025) and TAS from 1.87±0.31 to 1.68±0.20 mmol/L (P=0.030). For group B the ox-LDL changed from 62.9±29.7 to ± 61.4±14.6 U/L (P=0.168) and TAS from 1.87±0.51 to 1.68±0.20 mmol/L (P=0.168), while AOPP significantly decreased from 180.5±90.0 to 123.9±37.7 μmol/L (P=0.019). Conclusion. AOPP is more sensitive than ox-LDL for assessing OS after KT. TAS values appear to be insufficiently sensitive for monitoring OS in patients after KT. |
| Databáze: | OpenAIRE |
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