Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH)
| Autor: | Martin W. Elmlinger, Hans-Georg Lambrecht, Werner Kühnel, Michael B. Ranke |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Clinical Biochemistry Thyrotropin Thyroxine-binding globulin Thyroxine-Binding Proteins Thyroid-stimulating hormone Reference Values Internal medicine medicine Humans Euthyroid Child Immunoassay Triiodothyronine biology business.industry Biochemistry (medical) Thyroid Puberty Age Factors Infant Newborn Infant General Medicine Thyroxine medicine.anatomical_structure Endocrinology El Niño Child Preschool Luminescent Measurements biology.protein Female Thyroxine-binding proteins Thyroid function business Blood Chemical Analysis |
| Zdroj: | Clinical chemistry and laboratory medicine. 39(10) |
| ISSN: | 1434-6621 |
| Popis: | Disorders in thyroid function can impair normal development in children. Therefore it was our aim to establish reference intervals for serum triiodothyronine (T3), free T3 (fT3), thyroxine (T4), free T4 (fT4), thyroxine binding globulin (TBG) and thyrotropin (TSH) which are applicable from birth to adulthood by using the non-isotopic automated chemiluminescence immunoassay system, Immulite (DPC Los Angeles, USA). Serum samples from 762 euthyroid newborns, children and adolescents (369 female, 393 male; age 1 day to 19 years) were examined; of these, 381 were classified as pubertal. Due to non-normal distribution, the 2.5th, 50th and 97.5th percentiles (the central 95% interval) were calculated for each group. The median concentrations of T4, fT4 and TSH were up to 3.2-fold higher during the first 2 weeks, while T4 increased during the first month of life. The concentrations in all age groups showed no sex differences. From 1 year onwards, the concentration of all parameters tended to decrease until adult age, with the exception of TBG which increased by >60% (p |
| Databáze: | OpenAIRE |
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