Correction:Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort
| Autor: | Livia A. Carvalho, Amy M. Mason, Verena Zuber, Jessica M. B. Rees, Stephen Burgess, Christopher N. Foley, Gulam Khandaker, Apostolos Gkatzionis, Peter B. Jones |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Heart disease Population Coronary Disease Polymorphism Single Nucleotide Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Risk Factors Internal medicine Mendelian randomization medicine Genetics Odds Ratio Humans Family history education Molecular Biology Depression (differential diagnoses) Triglycerides Aged education.field_of_study business.industry Depression Interleukin-6 Correction Diagnostic markers Odds ratio Mendelian Randomization Analysis Middle Aged medicine.disease Comorbidity United Kingdom Psychiatry and Mental health 030104 developmental biology C-Reactive Protein Female business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Khandaker, G M, Zuber, V, Rees, J M B, Carvalho, L, Mason, A M, Foley, C N, Gkatzionis, A, Jones, P B & Burgess, S 2020, ' Correction : Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort ', Molecular Psychiatry, vol. (2020) 25, pp. 1477-1486 . https://doi.org/10.1038/s41380-020-0857-7 Molecular Psychiatry |
| DOI: | 10.1038/s41380-020-0857-7 |
| Popis: | While comorbidity between coronary heart disease (CHD) and depression is evident, it is unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703 unrelated middle-aged participants of European ancestry from UK Biobank, a population-based cohort study, to assess whether comorbidity is primarily due to genetic or environmental factors, and to test whether cardiovascular risk factors and CHD are likely to be causally related to depression using Mendelian randomization. We showed family history of heart disease was associated with a 20% increase in depression risk (95% confidence interval [CI] 16–24%, p |
| Databáze: | OpenAIRE |
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