Enhanced bacterial uptake of I-131-labeled antimicrobial imidazolium bromide salts using fluorescent carbon nanodots
| Autor: | Suleyman Gokhan Colak, Melis Ozge Alas, Rükan Genç, Kasim Ocakoglu, Ismail Ozturk, Fatma Yurt, Ayça Tunçel, Ali Niyazi Duman, Ozge Er |
|---|---|
| Přispěvatelé: | Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
02 engineering and technology 010402 general chemistry medicine.disease_cause 01 natural sciences chemistry.chemical_compound Bromide Materials Chemistry medicine Side chain Molecule Carbon dots General Materials Science Escherichia coli Alkyl chemistry.chemical_classification Radiolabelling Gram-positive bacteria 021001 nanoscience & nanotechnology Fluorescence Combinatorial chemistry Naphthalimide 0104 chemical sciences Imidazolium salts chemistry Mechanics of Materials Lipophilicity Antibacterial activity Nanocarriers 0210 nano-technology |
| Popis: | Imidazolium bromide salts have been shown as potent antibiotic molecules that show structure-based bioactivity related to their cation alkyl side chain length. To enhance the bioavailability of lipophilic alkyl side chains herein, a 1,8-naphthalimide group containing imidazolium bromide salts bearing different lengths of alkyl chains (NIM1, 2, and 3) are coupled with fluorescent carbon dots (C-NIMs) through electrostatic and pi-pi interactions. Further, obtained nanocarriers were radio-labeled with iodine-131 (131I) to track the bacterial uptake of them by Staphylococcus aureus and Escherichia coli. Antibacterial activities were also investigated by the microdilution method. Comparison studies showed that both radiolabeling efficiency and lipophilicity increased when NIMs were integrated onto the CDots. More importantly, CDots resulted in 4-fold enhanced uptake of NIM1 by S. aureus bacterium as compared to pristine imidazolium bromide salts while at a higher number of alkyl chain lengths enhancement was 2-fold. |
| Databáze: | OpenAIRE |
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