Endoscopic factors influencing fecal calprotectin value in crohn's disease
| Autor: | Bruno Pereira, Anthony Buisson, Marion Goutte, R Minet-Quinard, Gilles Bommelaer, A.-L. Boucher, Felix Goutorbe |
|---|---|
| Přispěvatelé: | CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA), Unité de Biochimie, Centre hospitalier universitaire de Nantes (CHU Nantes) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty [SDV]Life Sciences [q-bio] Colonoscopy Sensitivity and Specificity Severity of Illness Index Gastroenterology Feces 03 medical and health sciences 0302 clinical medicine Crohn Disease Internal medicine Severity of illness Humans Medicine Single-Blind Method Prospective Studies endoscopy Prospective cohort study Aged Crohn's disease Univariate analysis Crohn' s disease medicine.diagnostic_test Receiver operating characteristic business.industry Crohn's Disease Endoscopic Index of Severity General Medicine Middle Aged medicine.disease fecal calprotectin 3. Good health ROC Curve 030220 oncology & carcinogenesis Multivariate Analysis Biomarker (medicine) biomarker Female 030211 gastroenterology & hepatology Calprotectin business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Journal of Crohn's and Colitis Journal of Crohn's and Colitis, Elsevier-Oxford University Press, 2015, 9 (12), pp.1113-1119. ⟨10.1093/ecco-jcc/jjv150⟩ |
| ISSN: | 1873-9946 1876-4479 |
| DOI: | 10.1093/ecco-jcc/jjv150⟩ |
| Popis: | International audience; Background and Aims: Fecal calprotectin [fcal] is a biomarker of Crohn's disease [CD] endoscopic activity. Identifying the endoscopic situations in which fcal is less reliable remains unexplored. We aimed to determine the endoscopic factors influencing fcal level in CD. Methods: Overall, 53 CD patients consecutively and prospectively underwent colonoscopy, with CD Endoscopic Index of Severity [CDEIS] calculation and stool collection. Fcal was measured using a quantitative immunochromatographic test. Correlation analysis was done with Pearson statistics. Results: Fcal was correlated with CDEIS [0.66, p < 0.001]. In univariate analysis, fcal was correlated with the affected surface [0.65, p < 0.001] and the ulcerated surface [0.47, p < 0.001]. Fcal was significantly associated with ulceration depth, with median fcal of 867.5 mu g/g, 1251.0 mu g/g, and 1800.0 mu g/g, in patients presenting with non-ulcerated lesions, superficial ulcerations [SU], and deep ulcerations [DU], respectively. Lesion locations did not influence fcal. In multivariate analysis, fcal was associated with affected surface [p = 0.04] and the presence of CD lesions. Moreover, fcal increased with the ulceration depth [p = 0.03]. However, ulcerated surface and CD location did not affect fcal. Using a receiver operating characteristic [ROC] curve, we showed that fcal of 400 mu g/g was the best compromise between sensitivity [0.76] and specificity [0.77], whereas fcal >= 200 mu g/g was highly sensitive [0.86] to detect SU or DU. Conclusions: Fcal is a very reliable biomarker to detect endoscopic ulcerations in CD. We suggest repeating measurement in case of intermediary results [200-400 mu g/g] in daily practice. Fcal level is mostly influenced by the presence of CD lesions [even non-ulcerated], in a depth-related manner and by the affected surface. |
| Databáze: | OpenAIRE |
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