Influence of the vinyl group on the calcium antagonistic activity of analogues of Fostedil
| Autor: | J Tisne-Versailles, G. Baziard-Mouysset, J.L. Stigliani, R Bonnafous, G. Tchani, M. Payard |
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| Rok vydání: | 1994 |
| Předmět: |
Vinyl Compounds
chemistry.chemical_element Aorta Thoracic In Vitro Techniques Calcium Medicinal chemistry chemistry.chemical_compound Smooth muscle medicine Animals Benzothiazoles General Pharmacology Toxicology and Pharmaceutics Fostedil integumentary system Chemistry organic chemicals Aryl Aromaticity Calcium Channel Blockers In vitro Thiazoles Biochemistry Molecular Medicine Rabbits medicine.symptom Muscle Contraction Muscle contraction |
| Zdroj: | Pharmaceutica Acta Helvetiae. 68:173-179 |
| ISSN: | 0031-6865 |
| DOI: | 10.1016/0031-6865(94)90040-x |
| Popis: | Four aryl vinyl diethyl benzylphosphonates related to Fostedil were synthesized and evaluated for their in vitro calcium-inhibitory activity. None of these compounds exhibited any calcium antagonistic profile. Unlike a series of diethyl-styryl benzylphosphonates, previously described, the presence of two aromatic rings linked by a vinyl group did not improve the calcium antagonistic activity. |
| Databáze: | OpenAIRE |
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