Synthesis of new diselenide compounds as anti-inflammatory agents
| Autor: | Jin Hyun Jeong, Kyung-Tae Lee, Kyung-Min Shin, Liu-Lan Shen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Cell Survival
medicine.drug_class Pharmacology toxicology Nitric Oxide Synthase Type II Anti-inflammatory Cell Line Diselenide Mice Selenium Organoselenium Compound Organoselenium Compounds Drug Discovery polycyclic compounds medicine Animals Organic chemistry heterocyclic compounds chemistry.chemical_classification Dose-Response Relationship Drug Chemistry organic chemicals Anti-Inflammatory Agents Non-Steroidal Organic Chemistry In vitro Isoenzymes Enzyme Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Molecular Medicine Nitric Oxide Synthase |
| Zdroj: | Archives of Pharmacal Research. 27:816-819 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/bf02980171 |
| Popis: | Many diselenide compounds are used as antioxidants, enzyme inhibitors and cytokine inducers. Three new diselenide compounds, bis-(2-hydroxyphenyl) diselenide, bis-(3-hydroxyphenyl) diselenide and bis-(4-hydroxyphenyl) diselenide were designed and synthesized as anti-inflammatory agent. All of them were found to have strong in vitro activity in anti-inflammatory assays. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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