Comparison of physical and biological properties of CardioCel® with commonly used bioscaffolds
| Autor: | Kirsten Puls, William M L Neethling, Alethea Rea |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Biocompatibility Swine Rat model 02 engineering and technology 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cardiovascular procedures Biological property Elastic Modulus Tensile Strength Medicine Pericardium Animals Decellularization Tissue Scaffolds business.industry 021001 nanoscience & nanotechnology medicine.disease Rats medicine.anatomical_structure chemistry Models Animal Surgery Cattle Glutaraldehyde 0210 nano-technology Cardiology and Cardiovascular Medicine business Calcification Biomedical engineering |
| Zdroj: | Interactive cardiovascular and thoracic surgery. 26(6) |
| ISSN: | 1569-9285 |
| Popis: | OBJECTIVES Durability of bioscaffolds cross-linked with glutaraldehyde and used in cardiovascular surgery is limited by biomechanical instability, calcification and reduced biocompatibility. This study compares CardioCel®, a bovine pericardial scaffold engineered via the ADAPT® process to ensure optimized biostability and biocompatibility, with the commonly used bioscaffolds. METHODS Bovine pericardial scaffolds, cross-linked with 0.6% glutaraldehyde (XenoLogiX™, PeriGuard®), dye-mediated photo-oxidized (PhotoFix™) and a non-crosslinked porcine scaffold (CorMatrix®), were compared with CardioCel (decellularized, cross-linked with 0.05% monomeric glutaraldehyde, detoxified) by thermal stability and mechanical tests. Biocompatibility and calcification were assessed in a juvenile subcutaneous rat model at 6 and 12 weeks. RESULTS CardioCel displayed significantly higher (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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