Synthesis of a new class of bis(thiourea)hydrazide pseudopeptides as potential inhibitors of β-sheet aggregation

Autor:	Jan Jasper Klein, Stefan Hecht
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Scaffold Molecular Structure Stereochemistry Organic Chemistry Beta sheet Peptide Hydrazide Biochemistry Combinatorial chemistry Protein Structure Secondary chemistry.chemical_compound Hydrazines chemistry Thiourea Urea Physical and Theoretical Chemistry Peptides
Zdroj:	Organic letters. 14(1)
ISSN:	1523-7052
Popis:	The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display “amphifinity”, i.e. association with a peptide strand on one but not the other face of the scaffold, and hence could potentially inhibit β-sheet aggregation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695a41a3c58b39a021a08e7107247810 https://pubmed.ncbi.nlm.nih.gov/22168336 Zobrazit plný text záznamu