Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment
| Autor: | Rute F. Vitor, Ghaleb A. Husseini, Omar Guessoum, Najla M Salkho, R Z Turki, Ana M. Martins |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Antineoplastic Agents
02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Drug Delivery Systems In vivo Neoplasms Medicine Animals Humans Ultrasonics Molecular Biology Liposome Drug Carriers business.industry Ultrasound Cancer General Medicine 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Cancer treatment Drug delivery Liposomes Drug release Molecular Medicine Nanoparticles 0210 nano-technology business Drug carrier Biomedical engineering |
| Zdroj: | Current molecular medicine. 17(10) |
| ISSN: | 1875-5666 |
| Popis: | The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues. In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed. |
| Databáze: | OpenAIRE |
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