Maternal Serum Levels of Zinc, Copper, and Thiols in Preeclampsia Patients: a Case-Control Study
| Autor: | Sahabettin Selek, Tugce Yıldız, Yıldız Atamer, Nil Atakul, Ufuk Sarıkaya, Metin Demirel, Ayse Zehra Gul |
|---|---|
| Přispěvatelé: | YILDIZ, TUĞÇE |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Clinical Biochemistry a Case-Control Study.- Biological trace element research 2021 [Gul A. Z. Atakul N. Selek Ş. Atamer Y. Sarıkaya U. Yıldız T. Demirel M. -Maternal Serum Levels of Zinc Copper and Thiols in Preeclampsia Patients] chemistry.chemical_element Context (language use) Zinc 010501 environmental sciences medicine.disease_cause 01 natural sciences Biochemistry Preeclampsia Inorganic Chemistry Pathogenesis 03 medical and health sciences Pre-Eclampsia Pregnancy Internal medicine medicine Humans Sulfhydryl Compounds 0105 earth and related environmental sciences chemistry.chemical_classification 0303 health sciences business.industry 030302 biochemistry & molecular biology Biochemistry (medical) Case-control study General Medicine medicine.disease Copper Endocrinology chemistry Case-Control Studies Thiol Female business Oxidative stress |
| Popis: | Preeclampsia is one of the leading causes of maternal mortality-morbidity, and environmental factors act as the main driving force for the development of disease in genetically lean women. Trace element levels (zinc, copper) and thiol state (total, native thiol) may affect involved risk factors and play a role in the pathogenesis. The objective of our study is to assess trace element and thiol levels in patient and control groups. A total number of 88 pregnant women (in their third trimester) included 43 preeclampsia patients and 45 normotensive pregnant women as controls. The main findings of this study were the significantly elevated copper levels and decreased thiol levels (native and total thiols) in the patient group compared to controls (p0.05). Disulfide levels were not statistically different between the groups (p0.05). In patients, the predictive cutoff value of copper was 224 μg/dL and was 1.19 for the copper/native thiol ratio. Zinc levels were not statistically different between the two groups. Correlation analysis revealed no relationship between zinc-copper and zinc-total thiol levels in patients, while a positive correlation was evident in controls (zinc-copper, p0.05, r = 0.425, and zinc-total thiol levels, p0.05, r = 0.642). Patients had marginally high ALT and AST values in the normal range, and a significant difference was found between the two groups (p0.05). According to these results, elevated copper levels and decreased thiol levels may have a value for early prediction. The mechanisms that may be responsible for the altered element and thiol status have been discussed here in the context of oxidative stress. |
| Databáze: | OpenAIRE |
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